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Associations between abdominal obesity indices with hypertension in type 2 diabetes mellitus: Chinese visceral adiposity index

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Abstract

Purpose

This research was performed to evaluate the relationship between hypertension (HTN) and abdominal obesity index in patients with type 2 diabetes mellitus (T2DM).

Methods

Totally 1657 participants with T2DM (mean age 54 ± 12 years; 38.02% female) were enrolled. They were divided into the groups of HTN (n = 775) and non-HTN (n = 882). Anthropometric and biochemical indicators were measured and collected. A bioelectrical impedance analyzer was used to measure visceral and subcutaneous fat areas.

Results

Compared with the HTN group, the non-HTN group had a lower level of Chinese visceral adiposity index (CVAI) (p < 0.001). Meanwhile, among tertiles of CVAI, as CVAI increased, the proportion of patients with HTN increased, which was 33.51%, 44.30%, and 62.50%, respectively. CVAI was shown to have a significant positive correlation with HTN. (r = 0.258, p < 0.001). CVAI was independently related to an elevated risk of HTN by binary logistic regression analyses, and the OR was (95% CI) 1.013 (1.010–1.016, p < 0.001) after adjustment. The area under the receiver operating characteristic curve (AUC) of CVAI predicted HTN in T2DM patients was greater than those of other abdominal obesity indices (p < 0.001).

Conclusion

We found that CVAI was highly positively correlated with HTN in T2DM. Compared with other indices of abdominal obesity, such as WC, BMI, WHR, VAI, and LAP, the CVAI showed superior discriminative ability in T2DM complicated with HTN. Therefore, more attention should be paid to CVAI in T2DM.

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Data availability

The data that support the findings of this study are available on request from the corresponding author.

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Acknowledgements

The authors sincerely thank all participants in this study.

Funding

This study was supported by the National Natural Science Foundation of China (81500351), the Youth Medical Talent Project of Jiangsu Province (QNRC2016842), the Science and Technology Commission of Zhenjiang City (FZ2020038), Doctoral Research Initiation Fund (jdfyRC2020010), Clinical Medical Science and Technology Development Foundation of Jiangsu University (JLY2021209), Key project for Medical Education Collaborative Innovation Fund of Jiangsu University (JDY2022005), the open project of clinical medical research center of Gynecology and Traditional Chinese Medicine of Zhenjiang (SS202204-KFB05).

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Affiliated Hospital of Jiangsu University, Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang, China

    C. Cheng, X. Yu, K. Shi, G. Dai, Q. Pan, G. Yuan & J. Jia

Authors
  1. C. Cheng
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  2. X. Yu
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  3. K. Shi
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  4. G. Dai
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  5. Q. Pan
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  6. G. Yuan
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  7. J. Jia
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Contributions

JJ and GY designed the study. CC, YX, SK, DG, PQ contributed to conduct the research and collect data. CC was responsible for analyzing the data and writing the paper. JJ made suggestions and revised the paper. The submitted version has been read and approved by all authors.

Corresponding authors

Correspondence to G. Yuan or J. Jia.

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The authors declare that they have no conflict of interest.

Ethical approval

This research complies with the principle of the Helsinki Declaration. All procedures performed in studies involving human participants were authorized by the Jiangsu University Affiliated Hospital Ethics Committee and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Cheng, C., Yu, X., Shi, K. et al. Associations between abdominal obesity indices with hypertension in type 2 diabetes mellitus: Chinese visceral adiposity index. J Endocrinol Invest 47, 547–555 (2024). https://doi.org/10.1007/s40618-023-02165-6

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  • DOI: https://doi.org/10.1007/s40618-023-02165-6

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