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Endocrinologists at work: management of hyponatremia in clinical practice

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References

  1. Sbardella E, Isidori AM, Arnaldi G et al (2018) Approach to hyponatremia according to the clinical setting: consensus statement from the Italian society of endocrinology (SIE), Italian society of nephrology (SIN), and Italian association of medical oncology (AIOM). J Endocrinol Invest 41:3–19. https://doi.org/10.1007/s40618-017-0776-x

    Article  CAS  PubMed  Google Scholar 

  2. Spasovski G, Vanholder R, Allolio B et al (2014) Clinical practice guideline on diagnosis and treatment of hyponatraemia. Eur J Endocrinol 170:G1-47. https://doi.org/10.1530/EJE-13-1020

    Article  CAS  PubMed  Google Scholar 

  3. Verbalis JG, Goldsmith SR, Greenberg A et al (2013) Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations. Am J Med 126:S1–S42. https://doi.org/10.1016/j.amjmed.2013.07.006

    Article  PubMed  Google Scholar 

  4. Corona G, Giuliani C, Parenti G et al (2013) Moderate hyponatremia is associated with increased risk of mortality: evidence from a meta-analysis. PLoS ONE 8:e80451. https://doi.org/10.1371/journal.pone.0080451

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Corona G, Norello D, Parenti G et al (2018) Hyponatremia, falls and bone fractures: a systematic review and meta-analysis. Clin Endocrinol (Oxf) 89:505–513. https://doi.org/10.1111/cen.13790

    Article  PubMed  Google Scholar 

  6. Suárez V, Norello D, Sen E et al (2020) Impairment of neurocognitive functioning, motor performance, and mood stability in hospitalized patients with euvolemic moderate and profound hyponatremia. Am J Med 133:986-993.e5. https://doi.org/10.1016/j.amjmed.2019.12.056

    Article  CAS  PubMed  Google Scholar 

  7. Ahluwalia V, Wade JB, Thacker L et al (2013) Differential impact of hyponatremia and hepatic encephalopathy on health-related quality of life and brain metabolite abnormalities in cirrhosis. J Hepatol 59:467–473. https://doi.org/10.1016/j.jhep.2013.04.023

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Corona G, Giukiani C, Parenti G et al (2016) The economic burden of hyponatremia: systematic review and meta-analysis. Am J Med 129:823-835.e4. https://doi.org/10.1016/j.amjmed.2016.03.007

    Article  PubMed  Google Scholar 

  9. Greenberg A, Verbalis JG, Amin AN et al (2015) Current treatment practice and outcomes. Report of the hyponatremia registry. Kidney Int 88:167–177. https://doi.org/10.1038/ki.2015.4

    Article  PubMed  PubMed Central  Google Scholar 

  10. Tzoulis P, Waung JA, Bagkeris E et al (2016) Real-life experience of tolvaptan use in the treatment of severe hyponatraemia due to syndrome of inappropriate antidiuretic hormone secretion. Clin Endocrinol 84:620–626. https://doi.org/10.1111/cen.12943

    Article  CAS  Google Scholar 

  11. Mohmand HK, Issa D, Ahmad Z et al (2007) Hypertonic saline for hyponatremia: risk of inadvertent overcorrection. Clin J Am Soc Nephrol 2:1110–1117. https://doi.org/10.2215/CJN.00910207

    Article  PubMed  Google Scholar 

  12. Garrahy A, Dineen R, Hannon AM et al (2019) Continuous versus bolus infusion of hypertonic saline in the treatment of symptomatic hyponatremia caused by SIAD. J Clin Endocrinol Metab 104:3595–3602. https://doi.org/10.1210/jc.2019-00044

    Article  PubMed  Google Scholar 

  13. Rondon-Berrios H, Tandukar S, Mor MK et al (2018) Urea for the treatment of hyponatremia. Clin J Am Soc Nephrol 13:1627–1632. https://doi.org/10.2215/CJN.04020318

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Decaux G, Gankam Kengne F, Couturier B et al (2014) Actual therapeutic indication of an old drug: urea for treatment of severely symptomatic and mild chronic hyponatremia related to SIADH. J Clin Med 3:1043–1049. https://doi.org/10.3390/jcm3031043

    Article  PubMed  PubMed Central  Google Scholar 

  15. Nervo A, D’Angelo V, Rosso D et al (2019) Urea in cancer patients with chronic SIAD-induced hyponatremia: old drug, new evidence. Clin Endocrinol (Oxf) 90:842–848. https://doi.org/10.1111/cen.13966

    Article  CAS  PubMed  Google Scholar 

  16. Phillips GB, Schwartz R, Gabuzda GJ, Davidson CS (1952) The syndrome of impending hepatic coma in patients with cirrhosis of the liver given certain nitrogenous substances. N Engl J Med 247:239–246. https://doi.org/10.1056/NEJM195208142470703

    Article  CAS  PubMed  Google Scholar 

  17. Bioletto F, Varaldo E, Prencipe N et al (2023) Long-term efficacy of empagliflozin as an add-on treatment for chronic SIAD: a case report and literature review. Hormones (Athens). https://doi.org/10.1007/s42000-023-00430-0

    Article  PubMed  Google Scholar 

  18. Perelló-Camacho E, Pomares-Gómez FJ, López-Penabad L et al (2022) Clinical efficacy of urea treatment in syndrome of inappropriate antidiuretic hormone secretion. Sci Rep 12:10266. https://doi.org/10.1038/s41598-022-14387-4

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Division of Endocrinology and Metabolic Diseases, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, Ancona, Italy

    G. Arnaldi

  2. Oncological Endocrinology Unit, Department of Medical Sciences, University of Turin, Turin, Italy

    E. Arvat

  3. Division of Endocrinology, Diabetology and Metabolism, City of Health and Science University Hospital of Turin, Turin, Italy

    A. M. Berton

  4. Endocrinology Unit, Azienda AUSL, Bologna, Italy

    G. Corona

  5. Programma di Neurochirurgia Ipofisi - Pituitary Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy

    M. Faustini Fustini

  6. Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy

    E. Ferrante

  7. Endocrinology Unit, AO Ordine Mauriziano, Largo Turati 62, 10128, Turin, Italy

    P. Razzore

  8. Pituitary Diseases and Sodium Alterations Unit, Endocrinology, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Careggi University Hospital, Florence, Italy

    A. Peri

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Correspondence to A. Peri.

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The authors received a travel grant from Cantabria Labs Difa Cooper.

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Arnaldi, G., Arvat, E., Berton, A.M. et al. Endocrinologists at work: management of hyponatremia in clinical practice. J Endocrinol Invest 46, 2453–2457 (2023). https://doi.org/10.1007/s40618-023-02147-8

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