Fig. 1
From: Tissue and circulating microRNAs as biomarkers of response to obesity treatment strategies
Caloric restriction and/or bariatric surgery modulation of adipose tissue microRNAs. a Caloric Restriction. The increase of miR-29a-3p after caloric restriction was paralleled with lipoprotein lipase (LPL) reduction, while the reduction of miR-454-3p, miR-20b-5p and miR-210 were paralleled with the increase of other pivotal players in controlling weight loss and insulin resistance. Specifically, acyl-CoA synthetase long-chain family member 1 (ACSL1) up-regulation was related with miR-454-3p down-regulation. Monoglyceride lipase (MGLL) and solute carrier family 2 member 4 (SLC2A4) were related with miR-20b-5p modulation. While acyl-CoA synthetase long-chain family member 4 (ACSL4) and signal transducer and activator of transcription 3 (STAT3) up-regulation was related with both miR-454-3p and miR-20b-5p down-regulation. The reduction of miR-210 was coupled with Glycerol-3-Phosphate Dehydrogenase 1 Like (GPD1L) increase. b Bariatric surgery. The increase of miR-122 was linked with peroxisome proliferator-activated receptor γ (PPAR-γ), while miR-223-3p and miR-519d were related with glucose transporter 4 (GLUT-4) and PPAR-α up-regulation, respectively