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Age-related differences of immune infiltrates in pheochromocytomas and paragangliomas

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Fig. 1

Availability of data and material

All data used in the present study is publicly available at the referenced data repositories.

Code availability

All analyses were performed with R programming language. Code is available upon request.

References

  1. Pacak K, Eisenhofer G, Ahlman H et al (2007) Pheochromocytoma: recommendations for clinical practice from the First International Symposium. Nat Clin Pract Endocrinol Metab 3:92–102

    Article  Google Scholar 

  2. Lenders JW, Duh QY, Eisenhofer G et al (2014) Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 99:1915–1942. https://doi.org/10.1210/jc.2014-1498

    Article  CAS  PubMed  Google Scholar 

  3. Lefebvre M, Foulkes WD (2014) Pheochromocytoma and paraganglioma syndromes: genetics and management update. Curr Oncol 21:e8–e17

    Article  CAS  Google Scholar 

  4. Hendry S, Salgado R, Gevaert T et al (2017) Assessing tumor-infiltrating lymphocytes in solid tumors: a practical review for pathologists and proposal for a standardized method from the International Immunooncology Biomarkers Working Group: Part 1: assessing the host immune response, TILs in invasive breast carcinoma and ductal carcinoma in situ, metastatic tumor deposits and areas for further research. Adv Anat Pathol 24:235–251

    Article  Google Scholar 

  5. Bremnes RM, Al-Shibli K, Donnem T et al (2011) The role of tumor-infiltrating immune cells and chronic inflammation at the tumor site on cancer development, progression, and prognosis: emphasis on non-small cell lung cancer. J Thorac Oncol 6:824–833

    Article  Google Scholar 

  6. Thorsson V, Gibbs DL, Brown SD et al (2018) (2019) The Immune Landscape of Cancer. Immunity 48(4):812–830.e14 (published correction appears in Immunity. 51(2):411–412)

    Article  CAS  Google Scholar 

  7. Tamborero D, Rubio-Perez C, Muiños F et al (2018) A pan-cancer landscape of interactions between solid tumors and infiltrating immune cell populations. Clin Cancer Res 24(15):3717–3728

    Article  CAS  Google Scholar 

  8. Fishbein L, Leshchiner I, Walter V, Danilova L, Robertson AG, Johnson AR et al (2017) Comprehensive molecular characterization of pheochromocytoma and paraganglioma. Cancer Cell 31(2):181–193

    Article  CAS  Google Scholar 

  9. Newman AM, Steen CB, Liu CL et al (2019) Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat Biotechnol 37:773–782

    Article  CAS  Google Scholar 

  10. Porta-Pardo E, Godzik A (2016) Mutation drivers of immunological responses to cancer. Cancer Immunol Res 4(9):789–798

    Article  CAS  Google Scholar 

  11. Hadoux J, Terroir M, Leboulleux S et al (2017) Interferon-alpha treatment for disease control in metastatic pheochromocytoma/paraganglioma patients. Horm Cancer 8(5–6):330–337

    Article  CAS  Google Scholar 

  12. Kirkwood JM, Bender C, Agarwala S et al (2002) Mechanisms and management of toxicities associated with high-dose interferon alfa-2b therapy. J Clin Oncol 20(17):3703–3718

    Article  CAS  Google Scholar 

  13. Jayasingam SD, Citartan M, Thang TH, Mat Zin AA, Ang KC, Ch'ng ES (2020) Evaluating the polarization of tumor-associated macrophages into M1 and M2 phenotypes in human cancer tissue: technicalities and challenges in routine clinical practice. Front Oncol 9:1512

    Article  Google Scholar 

  14. Ohue Y, Nishikawa H (2019) Regulatory T (Treg) cells in cancer: can Treg cells be a new therapeutic target? Cancer Sci 110:2080–2089

    Article  CAS  Google Scholar 

  15. Lee C, Jeong H, Bae Y et al (2019) Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide. J Immunother Cancer 7:147

    Article  Google Scholar 

  16. Tay RE, Richardson EK, Toh HC (2020) Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms. Cancer Gene Ther. https://doi.org/10.1038/s41417-020-0183-x

    Article  PubMed  PubMed Central  Google Scholar 

  17. Zhao X, Lei Y, Li G, Cheng Y, Yang H et al (2019) Integrative analysis of cancer driver genes in prostate adenocarcinoma. Mol Med Rep 19:2707–2715

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Kim N, Hong Y, Kwon D, Yoon S (2013) Somatic mutaome profile in human cancer tissues. Genomics Inform 11(4):239–244

    Article  Google Scholar 

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Funding

Not applicable. No funding was received for this study.

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Authors and Affiliations

  1. Cooper Medical School at Rowan University, 401 Broadway, Camden, NJ, 08103, USA

    S. Batchu

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  1. S. Batchu
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SB: conceptualization, methodology, software, visualization, investigation, writing—reviewing and editing.

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Correspondence to S. Batchu.

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Batchu, S. Age-related differences of immune infiltrates in pheochromocytomas and paragangliomas. J Endocrinol Invest 44, 1543–1546 (2021). https://doi.org/10.1007/s40618-020-01443-x

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