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Metabolic syndrome is associated to an increased risk of low bone mineral density in free-living women with suspected osteoporosis

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Abstract

Purpose

Osteoporosis (Op) and metabolic syndrome (MetS) are two common disorders showing common pathogenic patterns. This cross-sectional study was performed to evaluate if MetS and its constitutive elements are associated to an increased risk of low bone mineral density (BMD) in free-living women examined by Dual-energy X-ray absorptiometry (DXA) for suspected Op.

Methods

13,182 free-living Caucasian women referring to “COMEGEN” general practitioners cooperative operating in Naples, Italy, performed a contextual evaluation of BMD by DXA and all MetS constitutive elements (systolic and diastolic blood pressure, waist circumference, serum levels of triglycerides, high-density lipoprotein cholesterol, and fasting glucose) between June 1st 2008 and May 31st 2018. Subjects aged less than 40 years or with signs or symptoms suggestive of secondary Op were excluded from the study.

Results

MetS is associated to an increased risk of low BMD (Odds Ratio 1.19; 95% Confidence Interval 1.08–1.31). Among MetS constitutive elements, hypertension was associated to increased risk of low BMD, whereas high fasting glucose level/diabetes were associated to reduced risk of low BMD.

Conclusions

The significant association between Op and MetS in free-living women examined by DXA for suspected Op suggests the advisability of a contextual evaluation of both disorders in this setting.

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Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Funding

This is an unfounded study.

Author information

Authors and Affiliations

  1. Department of Clinical Medicine and Surgery, Federico II University, 80131, Naples, Italy

    D. Rendina, L. D’Elia, M. Evangelista, A. Giaquinto, V. Abate & P. Strazzullo

  2. Assistance Publique–Hôpitaux de Paris, Hôpital Robert Debré, Service d’Endocrinologie et Diabétologie Pédiatrique, 48, Boulevard Sérurier, 75019, Paris, France

    G. De Filippo

  3. Department of Neuroscience, Reproductive Sciences and Dentistry, Federico II University, 80131, Naples, Italy

    B. Barone & D. Prezioso

  4. “COMEGEN” Medical Cooperative, 80126, Naples, Italy

    G. Piccinocchi

Authors
  1. D. Rendina
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  2. L. D’Elia
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  3. M. Evangelista
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  4. G. De Filippo
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  5. A. Giaquinto
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  6. V. Abate
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  7. B. Barone
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  8. G. Piccinocchi
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  9. D. Prezioso
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  10. P. Strazzullo
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Contributions

All authors contributed to the study conception and design. Material preparation, and data collection were performed by DR, GP, GDF, AG, VA, BB and ME. The statistical analysis was performer by LD. The first draft of the manuscript was written by DR and GDF. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to G. De Filippo.

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Conflict of interest

The authors declare that they have no conflict of interest

Ethical approval

This retrospective study involving human participants was performed in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study protocol was approved by the ASL Naples 1 Ethical Committee, protocol number 0018508/2018.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Rendina, D., D’Elia, L., Evangelista, M. et al. Metabolic syndrome is associated to an increased risk of low bone mineral density in free-living women with suspected osteoporosis. J Endocrinol Invest 44, 1321–1326 (2021). https://doi.org/10.1007/s40618-020-01428-w

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  • DOI: https://doi.org/10.1007/s40618-020-01428-w

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