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Aqueous extract of Solanum macrocarpon Linn leaves abates hyperglycaemia and expression of glucose transporters gene in alloxan-induced diabetic rats

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Abstract

Purpose

In this study, antihyperglycaemic and level of gene expression of glucose transporters in alloxan-induced diabetic rats administered aqueous extract of S. macrocarpon leaves were assessed.

Method and results

Diabetes was induced by a single intraperitoneal (I.P) injection of freshly prepared alloxan. The animals were divided into six groups, euthanized on the fourteenth day of the experiment and different hyperglycaemic parameters were evaluated. Administration of different doses of the plant extract significantly (p < 0.05) reduced the fasting blood glucose level, glycated haemoglobin, serum lipid profiles, lipid peroxidation, and glucose-6-phosphatase. There was a significant (p < 0.05) increase in liver glycogen content, antioxidant enzyme activities, hexokinase activity, and expression of glucose transporter genes (GLUT-2 and GLUT-4) in diabetic rats administered different doses of S. macrocarpon.

Conclusion

It can be concluded that the aqueous extract of S. macrocarpon leaves could be helpful in the management of diabetes mellitus and its metabolic complications.

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Acknowledgements

The authors wish to express their gratitude to the support received by the South African Medical Research Council (SAMRC) through funding received from the South African National Treasury. Also, its contents are mainly the responsibility of the authors and do not necessarily represent the official views of the South African Medical Research Council.

Funding

This study was supported by the South African Medical Research Council through funding collected from the South African National Treasury.

Author information

Author notes

  1. O. A. Ojo

    Present address: Department of Biochemistry, Landmark University, Omu-Aran, Kwara State, Nigeria

Authors and Affiliations

  1. Phytomedicine, Biochemical Toxicology and Biotechnology Laboratory, Department of Biochemistry, College of Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria

    B. O. Ajiboye, B. E. Oyinloye, O. S. Owero-ozeze, I. L. Ekakitie & O. A. Ojo

  2. Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, 3886, South Africa

    B. E. Oyinloye

  3. Department of Biochemistry, Covenant University, Ota, Ogun State, Nigeria

    M. A. Okesola

  4. Molecular Biophysics and Structural Biology Group, Department of Biochemistry, Faculty of Science, University of Johannesburg, Johannesburg, South Africa

    A. P. Kappo

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Correspondence to B. O. Ajiboye.

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This study was done following the Animal Ethical Committee of Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.

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Ajiboye, B.O., Oyinloye, B.E., Owero-ozeze, O.S. et al. Aqueous extract of Solanum macrocarpon Linn leaves abates hyperglycaemia and expression of glucose transporters gene in alloxan-induced diabetic rats. J Endocrinol Invest 44, 265–276 (2021). https://doi.org/10.1007/s40618-020-01280-y

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