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High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes

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Abstract

Purpose

Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation. The aim of this study was to evaluate the association of OPN with fracture prevalence and with metabolic parameters in post-menopausal women with T2DM.

Methods

Sixty-four post-menopausal women with T2DM (age 67.0 ± 7.8 years, diabetes duration 8.9 ± 6.7 years), enrolled in a previous study, were followed up (3.6 ± 0.9 years). Previous fragility fractures were recorded. The FRAX score (without BMD) was calculated and biochemical parameters (plasma glucose, HbA1c, lipid profile and renal function) were assessed. Serum 25OH-vitamin D, calcium, PTH and OPN were evaluated at baseline. The association between OPN and fracture prevalence at baseline was evaluated by a logistic model.

Results

OPN levels were higher in patients with previous fractures (n.25) than in patients without previous fractures at baseline (n.39) (p = 0.006). The odds of having fractures at baseline increased by 6.7 (1.9–31.4, 95% CI, p = 0.007) for each increase of 1 ng/ml in OPN levels, after adjustment for vitamin D and HbA1c levels. Fracture incidence was 4.7%. Higher OPN associated with a decrease in HDL-cholesterol (p = 0.048), after adjustment for age, basal HDL-cholesterol, basal and follow-up HbA1c and follow-up duration. 25OH-vitamin D associated with an increase in FRAX-estimated probability of hip fracture at follow-up (p = 0.029), after adjustment for age, 25OH-vitamin D and time.

Conclusions

In post-menopausal women with T2DM, OPN might be a useful marker of fracture and worse lipid profile.

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Acknowledgements

This research did not receive any specific grant from funding agencies in the public, commercial, or no-for-26 profit sectors.

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Authors and Affiliations

  1. Department of Experimental Medicine, Policlinico Umberto I, “Sapienza” University of Rome, Viale del Policlinico 155, 00161, Rome, Italy

    T. Filardi, F. Tavaglione, A. Lenzi, E. Romagnoli & S. Morano

  2. Unit of Internal Medicine, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy

    V. Carnevale

  3. Department of Experimental Medicine and Surgery, Tor Vergata University, Rome, Italy

    R. Massoud & C. Russo

  4. Faculty of Economics, UNINT University, Rome, Italy

    L. Nieddu

  5. Department of Public Health and Infectious Diseases, “Sapienza” University, Rome, Italy

    I. Turinese

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  1. T. Filardi
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Correspondence to S. Morano.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

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Informed consent was obtained from all individual participants included in the study.

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Filardi, T., Carnevale, V., Massoud, R. et al. High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes. J Endocrinol Invest 42, 295–301 (2019). https://doi.org/10.1007/s40618-018-0914-0

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  • DOI: https://doi.org/10.1007/s40618-018-0914-0

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