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Predictors of fat-free mass loss 1 year after laparoscopic sleeve gastrectomy

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Abstract

Purpose

Laparoscopic sleeve gastrectomy (LSG) is one of the most frequently performed bariatric surgery interventions because of its safety and efficacy. Nevertheless, concerns have been raised on its detrimental effect on patient nutritional state that can ultimately lead to the loss of fat-free mass (FFM). There is interest in identifying predictors for the early identification of patients at risk of this highly unwanted adverse because they could benefit of nutritional preventive interventions. Therefore, we investigated whether anthropometric parameters, body composition or resting energy expenditure (REE) measured before surgery could predict FFM loss 1 year after LSG.

Methods

Study design was retrospective observational. We retrieved data on body weight, BMI, body composition and REE before and 1 year after LSG from the medical files of 36 patients operated on by LSG at our institutions. Simple regression, the Oldham’s method and multilevel analysis were used to identify predictors of FFM loss.

Results

Averaged percentage FFM loss 1 year after LSG was 17.0 ± 7.7% with significant differences between sexes (20.8 ± 6.6 in males and 12.2 ± 6.1% in females, p < 0.001). FFM loss was strongly predicted by pre-surgery FFM and this effect persisted also after correcting for the contribution of sex.

Conclusions

High FFM values before surgery predict a more severe FFM loss after LSG. This factor could also account for the higher FFM loss in men than in women. Our finding could help in the early identification of patient requiring a nutritional support after LSG.

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Author information

Authors and Affiliations

  1. Division of Physiology, Department of Clinical Medicine and Surgery, Federico II University of Naples, Via Pansini n°5, 80131, Naples, Italy

    B. Guida, M. L. Aiello, S. Parolisi & A. Belfiore

  2. Federico II University Hospital, Naples, Italy

    B. Guida, M. Cataldi, M. Musella, D. Capone & A. Belfiore

  3. Division of Pharmacology, Department of Neuroscience, Reproductive Sciences and Dentistry, Federico II University of Naples, Naples, Italy

    M. Cataldi

  4. Department of Medicine, University of Padova, Padua, Italy

    L. Busetto

  5. Division of Surgery, Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy

    M. Musella

  6. Division of Statistics, Department of Political Science, Federico II University of Naples, Naples, Italy

    V. Policastro & G. Ragozini

Authors
  1. B. Guida
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  2. M. Cataldi
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  3. L. Busetto
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  4. M. L. Aiello
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  5. M. Musella
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  6. D. Capone
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  7. S. Parolisi
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  8. V. Policastro
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  9. G. Ragozini
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  10. A. Belfiore
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Correspondence to B. Guida.

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Guida, B., Cataldi, M., Busetto, L. et al. Predictors of fat-free mass loss 1 year after laparoscopic sleeve gastrectomy. J Endocrinol Invest 41, 1307–1315 (2018). https://doi.org/10.1007/s40618-018-0868-2

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  • DOI: https://doi.org/10.1007/s40618-018-0868-2

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