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20S proteasome in the blood plasma of boys with cryptorchidism

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Abstract

Purpose

To evaluate the concentration of 20S proteasome in the blood plasma of boys with cryptorchidism.

Methods

Patients—50 boys aged 1–4 years (median = 2.4 years) with unilateral cryptorchidism. The control group—50 healthy, age-matched boys (aged 1–4 years, median = 2.1 years), admitted for planned herniotomy. In our study, we used a novel technique Surface PLASMON RESONANCE Imaging.

Results

The median concentration of 20S proteasome in the blood plasma of boys with cryptorchidism was 2.5-fold higher than in boys with inguinal hernia. We noticed statistically significant difference between 20S proteasome levels in boys with cryptorchidism up to 2 years old and above 2 years old.

Conclusions

We believe that the 20S proteasome concentrations in the blood plasma of boys with cryptorchidism reflect the heat-induced apoptosis of germ cells.

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Fig. 1
Fig. 2

Abbreviations

SPRI:

Surface plasmon resonance imaging

ZPAC:

Zygote-specific proteasome assembly chaperone

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Funding

No external funding for this manuscript.

Author information

Authors and Affiliations

  1. Paediatric Surgery Department, Medical University of Bialystok, Waszyngtona 17, 15-274, Bialystok, Poland

    D. Toliczenko-Bernatowicz, E. Matuszczak, M. Komarowska, W. Debek & A. Hermanowicz

  2. Biophysics Department, Medical University of Bialystok, Bialystok, Poland

    M. Tylicka

  3. Electrochemistry Department, University of Bialystok, Bialystok, Poland

    A. Sankiewicz & E. Gorodkiewicz

Authors
  1. D. Toliczenko-Bernatowicz
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  2. E. Matuszczak
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  3. M. Tylicka
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  4. A. Sankiewicz
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  5. M. Komarowska
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  6. E. Gorodkiewicz
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  7. W. Debek
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  8. A. Hermanowicz
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Corresponding author

Correspondence to E. Matuszczak.

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Conflict of interest

The other authors have indicated they have no potential conflicts of interest to disclose.

Ethical approval

The study was approved by the local Ethics Committee. All parents gave their informed, written consent for the inclusion to the study, clinical and biochemical follow-up, and for surgical treatment. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Study was approved by the Ethics Committee of Medical University of Bialystok Poland.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Financial disclosure

The other authors have indicated they have no financial relationships relevant to this article to disclose.

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Toliczenko-Bernatowicz, D., Matuszczak, E., Tylicka, M. et al. 20S proteasome in the blood plasma of boys with cryptorchidism. J Endocrinol Invest 41, 1103–1106 (2018). https://doi.org/10.1007/s40618-018-0851-y

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  • DOI: https://doi.org/10.1007/s40618-018-0851-y

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