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Hypertensive disorders during pregnancy and 3 years after delivery in women with gestational hyperglycemia

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Abstract

Aims

Women with gestational hyperglycemia commonly experience hypertensive disorders during pregnancy. More information is needed about how hypertension develops in these patients over time. We investigated the prevalence of hypertension during and 3 years after pregnancy in Caucasian women with gestational hyperglycemia. We also investigated metabolic syndrome presence, glucose tolerance status, insulin sensitivity and insulin secretion levels in the follow-up period.

Methods

In a prospective longitudinal study with a 3-year follow-up, we assessed hypertension status and clinical-related characteristics of 103 consecutive women with gestational hyperglycemia sub-grouped according to their hypertensive status during and after pregnancy.

Results

Overall, 29 (28.1%) women had hypertension during pregnancy (24 gestational hypertension; 4 chronic hypertension; 1 preeclampsia). At follow-up 16 (15.5%) women were diagnosed as having hypertension (11 with hypertension in pregnancy; 5 with a normotensive pregnancy). Women with hypertension after pregnancy had higher BMI, metabolic syndrome rate and worse insulin resistance indexes than normotensive women. Weight increase at follow-up (OR 1.17, 95% CI 1.00–1.35) and hypertension in pregnancy (OR 6.72, 95% CI 1.17–38.64) were associated with hypertension after pregnancy.

Conclusions

Women with gestational hyperglycemia should undergo regular monitoring during and after pregnancy to detect metabolic and clinical impairments and to prevent cardiovascular harm.

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Authors and Affiliations

  1. Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Via di Grottarossa, 1035-1039, 00189, Rome, Italy

    C. Festa, L. Mattei, O. Bitterman, M. Trappolini, A. Colatrella & A. Napoli

  2. Diabetology Unit, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3, 20162, Milan, Italy

    B. Pintaudi

  3. Department of Gynecology-Obstretics and Urology, Sapienza University of Rome, Rome, Italy

    M. Framarino dei Malatesta

  4. Department of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Rome, Italy

    P. Bianchi

Authors
  1. C. Festa
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  2. L. Mattei
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  3. O. Bitterman
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  4. B. Pintaudi
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  5. M. Framarino dei Malatesta
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  6. P. Bianchi
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  7. M. Trappolini
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  8. A. Colatrella
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  9. A. Napoli
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Correspondence to C. Festa.

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On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Festa, C., Mattei, L., Bitterman, O. et al. Hypertensive disorders during pregnancy and 3 years after delivery in women with gestational hyperglycemia. J Endocrinol Invest 41, 1075–1082 (2018). https://doi.org/10.1007/s40618-018-0833-0

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  • DOI: https://doi.org/10.1007/s40618-018-0833-0

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