Journal of Endocrinological Investigation

, Volume 41, Issue 4, pp 421–429 | Cite as

Interaction between gender and uric acid on hemoglobin A1c in community-dwelling persons

  • R. Kawamoto
  • D. Ninomiya
  • Y. Kasai
  • K. Senzaki
  • T. Kusunoki
  • N. Ohtsuka
  • T. Kumagi
Original Article



Higher glycated hemoglobin (Hb) (HbA1c) is significantly associated with an increased risk of cardiovascular disease (CVD). Serum uric acid (SUA) levels are associated with glucose intolerance and type 2 diabetes. Whether gender-specific differences regarding the relationship between SUA levels and HbA1c exist is unknown.


We recruited 1636 (men, 696 aged of 70 ± 10 years; women, 940 aged of 70 ± 9 years) participants and enrolled in the study during their annual health examination from a single community. We investigated the association between SUA levels and HbA1c within each gender.


Multiple linear regression analysis showed that in men, SUA (β = −0.091, p = 0.014) with prevalence of antidiabetic medication (β = 0.428, p < 0.001) and eGFR (β = 0.112, p = 0.016) were significantly and negatively associated with HbA1c, and in women, SUA (β = 0.101, p = 0.002) with prevalence of antidiabetic medication (β = 0.458, p < 0.001) were significantly and positively associated with HbA1c. Moreover, the interaction between gender and SUA (β = 0.445, p < 0.001) as well as gender (β = −0.465, p < 0.001), prevalence of antidiabetic medication (β = 0.444, p < 0.001), eGFRCKDEPI (β = 0.074, p = 0.014), and SUA (β = −0.356, p < 0.001) was a significant and independent determinant of HbA1c. A significant interactive effect of gender and SUA on determinants of HbA1c was noted in patients not on antidiabetic medications, regardless of age, HbA1c, and renal function.


The interaction between gender and SUA was associated with HbA1c independent of other metabolic factors in community-dwelling persons.


Interaction Gender Uric acid Hemoglobin A1c Community-dwelling persons 



This work was supported by a Grant-in-Aid for Scientific Research (C) (2015-2017). No additional external funding was received for this study. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interests.

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee at which the studies conducted (IRB Approval Number: 1402009).

Informed consent

Informed consent was obtained from all subjects participating in the study.


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Copyright information

© Italian Society of Endocrinology (SIE) 2017

Authors and Affiliations

  1. 1.Department of Community MedicineEhime University Graduate School of MedicineTōonJapan
  2. 2.Department of Internal MedicineSeiyo Municipal Nomura HospitalSeiyoJapan

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