Drug-induced obesity and its metabolic consequences: a review with a focus on mechanisms and possible therapeutic options

Review

Abstract

Weight gain is a common side effect of many widely used drugs. Weight gain of a few kilograms to an increase of 10% or more of initial body weight has been described. Not only the weight gain as such puts a burden on the health risks of the involved patients, the accompanying increase in the incidence of the metabolic syndrome, type 2 diabetes mellitus, and cardiovascular risk factors urges the caregiver to identify and to closely monitor the patients at risk. In this review, the different classes of drugs with significant weight gaining properties and the metabolic consequences are described. Specific attention is given to pathogenetic mechanisms underlying the metabolic effects and to potential therapeutic measures to prevent them.

Keywords

Drug-induced obesity Mechanisms Metabolic syndrome Antipsychotics Therapy 

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Copyright information

© Italian Society of Endocrinology (SIE) 2017

Authors and Affiliations

  1. 1.Department Endocrinology, Diabetology and MetabolismAntwerp University HospitalEdegemBelgium
  2. 2.Department of EndocrinologyZNA-Jan PalfijnAntwerpBelgium

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