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The effect of glycaemic control in type 2 diabetic patients with subclinical hypothyroidism

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Abstract

Objective

The purpose of this study was to investigate the effect of glycaemic control on subclinical hypothyroidism (SCH) in Chinese type 2 diabetic patients.

Methods

The study included 476 diabetic patients with SCH admitted for treatment of type 2 diabetes. The controls were selected euthyroid patients with similar characteristics regarding [age, body mass index (BMI), gender, previous hypertension or duration of diabetes, and smoke]. Total cholesterol (TC), LDL cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), the homeostatic model assessment of insulin resistance ratio (HOMA-IR), fasting plasma glucose, hemoglobin A1c (HbA1c), as well as plasma levels of thyrotrophin, and free thyroxine (FT4) were assessed at baseline and after 6 months of glycaemic control treatment.

Results

The LDL-C level and HOMA-IR value were significantly higher in the SCH group. Glycaemic control reduced HOMA-IR, HbA1c, LDL-C, and TG level in patients with SCH. Furthermore, glycaemic control plays a negative effect on thyrotrophin in the SCH group, while this effect was not observed in euthyroid subjects. HbA1c plays a positive correlation with HOMA-IR (r = 0.048, p < 0.001), fasting plasma glucose (r = 0.086, p < 0.001), LDL-C (r = 0.062, p < 0.001) and TG (r = 0.021, p = 0.009).

Conclusion

Our study shows that glycaemic control may bring some benefits to type 2 diabetic patients with SCH.

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Authors and Affiliations

  1. Renmin Hospital of Wuhan University, Wuhan, China

    X. Fu & H. Xia

  2. The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    H. Mao, S. Zhao & Z. Wang

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  1. X. Fu
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  2. H. Xia
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  3. H. Mao
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  4. S. Zhao
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Correspondence to H. Xia.

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Conflict of interest

The authors declare that they have no financial or personal relationship(s) that may have inappropriately influenced them in writing this article.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Fu, X., Xia, H., Mao, H. et al. The effect of glycaemic control in type 2 diabetic patients with subclinical hypothyroidism. J Endocrinol Invest 39, 1453–1458 (2016). https://doi.org/10.1007/s40618-016-0519-4

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  • DOI: https://doi.org/10.1007/s40618-016-0519-4

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