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Preoperative localization of an insulinoma: selective arterial calcium stimulation test performance

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Abstract

Purpose

Preoperative localization of an insulinoma is recommended to improve the cure rate, but non-invasive procedures can fail to detect the tumour. The objective of the study was to assess the performance of a selective arterial calcium stimulation test in the preoperative localization of insulinomas that were not detected by conventional imaging procedures.

Methods

We conducted a monocenter retrospective case review of 13 patients who had endogenous hyperinsulinism and were treated between 1994 and 2013. Patients were selected on the basis of negative or doubtful non-invasive preoperative imaging. A selective arterial calcium stimulation test was performed by pancreatic and hepatic arteriography with selective intra-arterial calcium stimulation and hepatic venous sampling in order to obtain the plasma insulin measurement. We evaluated the efficacy of the test by comparing the results with an endoscopic ultrasound.

Results

Twelve of the 13 patients underwent surgery, and the presence of an insulinoma was proven in 11 patients by pathological analysis of the tumour. An endoscopic ultrasound was consistent with surgery in 71.4 % of cases, while selective arterial calcium stimulation was consistent with surgery in 90.9 % and allowed detection of an insulinoma in two additional patients with a negative endoscopic ultrasound. One false-negative and one false-positive arterial calcium test were observed. No adverse events were recorded except transient skin flush following calcium injection in one patient.

Conclusion

The selective arterial calcium stimulation test is a sensitive diagnostic procedure for localizing insulinomas and may be considered when non-invasive radiological imaging does not allow the detection of an occult insulinoma.

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Authors and Affiliations

  1. Endocrinology Unit, Centre Hospitalo-Universitaire de Caen, Avenue de la côte de Nacre, CS 30001, 14033, Caen Cedex 9, France

    J. Morera, A. Guillaume, A. Rod, M. Joubert & Y. Reznik

  2. Diagnostic Radiology Unit, Centre Hospitalo-Universitaire de Caen, Avenue de la côte de nacre, CS 30001, 14033, Caen Cedex 9, France

    P. Courtheoux

  3. Endoscopic Ultrasound Unit, Trocadero Clinic, 75016, Paris, France

    L. Palazzo

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  1. J. Morera
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  2. A. Guillaume
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  3. P. Courtheoux
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  4. L. Palazzo
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional ethic committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Morera, J., Guillaume, A., Courtheoux, P. et al. Preoperative localization of an insulinoma: selective arterial calcium stimulation test performance. J Endocrinol Invest 39, 455–463 (2016). https://doi.org/10.1007/s40618-015-0406-4

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  • DOI: https://doi.org/10.1007/s40618-015-0406-4

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