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The correct renal function evaluation in patients with thyroid dysfunction

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Abstract

Thyroid dysfunction induces several renal derangements involving all nephron portions. Furthermore, dysthyroidism is a recognized risk factor associated with the development of chronic kidney disease. Current data, in fact, demonstrate that either subclinical or overt thyroid disease is associated with significant changes in creatinine, estimated glomerular filtration rate, measured glomerular filtration rate and Cystatin C. Herein, we systematically reviewed several relevant studies aiming at the identification of the most sensitive and specific parameter for the correct renal function evaluation in patients with thyroid dysfunction, that are usually treated as outpatients. Our systematic review indicates that estimated glomerular filtration rate, preferably with CKD-EPI equation, appears to be the most reliable and wieldy renal function parameter. Instead, Cystatin C should be better used in the grading of thyroid dysfunction severity.

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Abbreviations

CKD:

Chronic kidney disease

PAH:

Para-aminoippurate acid

GFR:

Glomerular filtration rate

RAAS:

Renin-angiotensin-aldosterone system

TSH:

Thyroid stimulating hormone

ADO:

Adenosine

Pi:

Phosphate

TBG:

Thyroxine binding globulin

SIADH:

Anti-diuretic hormone secretion syndrome

eGFR:

Estimated glomerular filtration rate

mGFR:

Measured glomerular filtration rate

Cys C:

Cystatin C

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Authors and Affiliations

  1. Nephrology and Dialysis Unit, ‘Magna Graecia’ University, 88100, Catanzaro, CZ, Italy

    Mariadelina Simeoni, Annamaria Cerantonio & Giorgio Fuiano

  2. Endocrinology Unit, ‘Magna Graecia’ University, 88100, Catanzaro, CZ, Italy

    Ida Pastore & Rossella Liguori

  3. Clinical Pathology Unit, ‘Magna Graecia’ University, 88100, Catanzaro, CZ, Italy

    Marta Greco, Daniela Foti, Elio Gulletta & Antonio Brunetti

  4. University Campus ‘Magna Graecia’, Viale Europa-Loc. Germaneto, 88100, Catanzaro, Italy

    Mariadelina Simeoni

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  1. Mariadelina Simeoni
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Correspondence to Mariadelina Simeoni.

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The authors have no conflict of interest to declare. This paper was not funded.

Ethical approval

In this systematic literature review all studies included in the analysis were conducted in accomplishment to the current legislation.

Informed consent

Informed consent was also obtained from all patients recruited in the reviewed studies.

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Simeoni, M., Cerantonio, A., Pastore, I. et al. The correct renal function evaluation in patients with thyroid dysfunction. J Endocrinol Invest 39, 495–507 (2016). https://doi.org/10.1007/s40618-015-0402-8

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  • DOI: https://doi.org/10.1007/s40618-015-0402-8

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