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Assessment of serum adiponectin in Egyptian patients with HCV-related cirrhosis and hepatocellular carcinoma

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Abstract

Background and aim

Hepatitis C-associated insulin resistance is involved in the development of various complications including hepatocarcinogenesis. Low plasma levels of adiponectin contribute to the pathogenesis of insulin resistance and type II diabetes mellitus. The aim of this study was to determine the value of serum adiponectin in Egyptian patients with hepatitis C-related cirrhosis and hepatocellular carcinoma.

Patients and methods

90 Egyptian patients with hepatitis C-related liver cirrhosis were enrolled in this study. Patients were divided into two groups as follows: group I: 61 patients with hepatitis C-related cirrhosis and hepatocellular carcinoma, group II: 29 patients with hepatitis C-related cirrhosis (hepatocellular carcinoma was excluded in these patients at the time of recruitment in the study). Serum adiponectin level was measured and correlated with all other studied parameters.

Results

Serum adiponectin was significantly lower in patients with hepatocellular carcinoma and it had significant negative correlations with both the overall tumor size and the number of tumor foci. Highly significant negative correlations were found between adiponectin and all markers of insulin resistance in both groups. At a cut-off value ≤5.4 μg/ml, adiponectin had a sensitivity of 60.7 %, a specificity of 93.1 %, a positive predictive value of 94.9 %, and a negative predictive value of 52.9 % for detection of hepatocellular carcinoma (with an overall accuracy of 77.6 %).

Conclusion

An independent association exists between serum adiponectin and hepatocellular carcinoma in Egyptian patients with hepatitis C-related cirrhosis. Therapy to increase circulating adiponectin concentration might represent a novel strategy to prevent hepatitis C-related hepatic complications.

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Acknowledgments

The authors would like to express their gratitude to all members of the Clinical Pathology Department of Ain Shams University Hospital for their valuable participation.

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Authors and Affiliations

  1. Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

    K. Hamdy, R. Al Swaff, H. A. Hussein & M. Gamal

Authors
  1. K. Hamdy
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  2. R. Al Swaff
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  3. H. A. Hussein
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  4. M. Gamal
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Corresponding author

Correspondence to R. Al Swaff.

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Conflict of interest

There is no conflict of interest regarding this work.

Ethical approval

The study was performed in the period between January 2014 and December 2014 according to the ethical standards for human experimentation approved by the human research committee of Ain Shams University Hospitals.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Hamdy, K., Al Swaff, R., Hussein, H.A. et al. Assessment of serum adiponectin in Egyptian patients with HCV-related cirrhosis and hepatocellular carcinoma. J Endocrinol Invest 38, 1225–1231 (2015). https://doi.org/10.1007/s40618-015-0379-3

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  • DOI: https://doi.org/10.1007/s40618-015-0379-3

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