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The impact of the presence of antithyroid antibodies on pregnancy outcome following intracytoplasmatic sperm injection-ICSI and embryo transfer in women with normal thyreotropine levels

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Abstract

Purpose

The aim of our study was to investigate the impact of anti-thyroid peroxidase antibodies (Anti-TPO) on pregnancy outcome following the in vitro fertilization and embryo transfer (IVF-ET) in general groups and in subgroups divided according to AMH level and age.

Methods

A total of 114 patients positive for anti-thyroid peroxidase antibodies (Anti-TPO+ group) and 495 infertile women negative for anti-thyroid peroxidase antibodies (Anti-TPO− group) undergoing IVF with ICSI from April 2010 to April 2012 were analyzed retrospectively.

Results

There were no significant differences in age, BMI, basal FSH, LH, AMH levels and duration of infertility between the two main groups. No significant differences in terms of the days of ovarian stimulation, estradiol level in day 8, total gonadotropin dose, number of oocytes retrieved, available embryos and blastocysts, number of embryos transferred nor in rates of fertilization, implantation, clinical pregnancy, live birth and abortion rate between two main groups were found. The only statistically significant difference among the groups with different anti-TPO antibodies levels was found in basal FSH concentration and BMI. Among the clinical outcomes of IVF with respect to the different anti-TPO levels, the only significant difference was found for the number of oocytes retrieved. Analysis of the baseline parameters in relationship to age categories and AMH levels found significant differences between women positive and negative for thyroid antibodies with respect to basal FSH and LH levels for women >37 years and for basal FSH in AMH <0.6 subgroup.

Conclusions

The present study reveals that patients with anti-TPO antibodies showed no significant differences in fertilization, implantation, pregnancy rates, live birth rates and no higher risk for miscarriage following IVF-ET when compared with those negative for anti-thyroid antibodies.

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Acknowledgments

The authors wish to thank the laboratory staff of Invicta Fertility Centre for the technical support in blood collecting and hormonal analyses. We wish to thank Mrs. A. Knight for native-speaker language editing.

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    Authors and Affiliations

    1. Department of Obstetrics and Gynecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland

      K. Łukaszuk, P. Kulwikowska & E. Pastuszek

    2. INVICTA Fertility and Reproductive Center, Gdańsk, Poland

      K. Łukaszuk, J. Liss & E. Pastuszek

    3. INVICTA Fertility and Reproductive Center, Invicta Złota 6 Str, 00019, Warsaw, Poland

      K. Łukaszuk & M. Kunicki

    4. Department of Chemical and Process Engineering Chemical Faculty, Gdansk University of Technology, Gdańsk, Poland

      M. Jaszczołt

    5. Department of Gynecological Endocrinology, Poznan Univeristy of Medcial Sciences, Poznan, Poland

      B. Męczekalski

    6. Institute of Computer Science, Faculty of Mathematics, Physics and Informatics, University of Gdansk, Gdańsk, Poland

      K. Skowroński

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    1. K. Łukaszuk
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    Correspondence to M. Kunicki.

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    All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards

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    K. Łukaszuk and M. Kunicki contributed equally to this work.

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    Łukaszuk, K., Kunicki, M., Kulwikowska, P. et al. The impact of the presence of antithyroid antibodies on pregnancy outcome following intracytoplasmatic sperm injection-ICSI and embryo transfer in women with normal thyreotropine levels. J Endocrinol Invest 38, 1335–1343 (2015). https://doi.org/10.1007/s40618-015-0377-5

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