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Circulating miRNAs as biomarkers for endocrine disorders

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Abstract

Specific, sensitive and non-invasive biomarkers are always needed in endocrine disorders. miRNAs are short, non-coding RNA molecules with well-known role in gene expression regulation. They are frequently dysregulated in metabolic and endocrine diseases. Recently it has been shown that they are secreted into biofluids by nearly all kind of cell types. As they can be taken up by other cells they may have a role in a new kind of paracrine, cell-to-cell communication. Circulating miRNAs are protected by RNA-binding proteins or microvesicles hence they can be attractive candidates as diagnostic or prognostic biomarkers. In this review, we summarize the characteristics of extracellular miRNA’s and our knowledge about their origin and potential roles in endocrine and metabolic diseases. Discussions about the technical challenges occurring during identification and measurement of extracellular miRNAs and future perspectives about their roles are also highlighted.

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Acknowledgments

This study has been funded by “Lendület” grant provided to Attila Patocs by Hungarian Academy of Sciences.

Conflict of interest

The authors declare that there is no conflict of interest.

Ethical approval

All procedures performing in studies involving human participants were in accordance with the ethical standards of institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent of the present retrospective study was waived.

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Authors and Affiliations

  1. Hungarian Academy of Sciences and Semmelweis University Molecular Medicine Research Group, Budapest, Hungary

    H. Butz, K. Racz & A. Patocs

  2. 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, 46 Szentkirályi Str., Budapest, 1088, Hungary

    N. Kinga, K. Racz & A. Patocs

  3. Hungarian Academy of Sciences and Semmelweis University “Lendület” Hereditary Endocrine Tumors Research Group, Budapest, Hungary

    H. Butz & A. Patocs

Authors
  1. H. Butz
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  2. N. Kinga
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  3. K. Racz
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  4. A. Patocs
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Correspondence to A. Patocs.

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Butz, H., Kinga, N., Racz, K. et al. Circulating miRNAs as biomarkers for endocrine disorders. J Endocrinol Invest 39, 1–10 (2016). https://doi.org/10.1007/s40618-015-0316-5

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  • DOI: https://doi.org/10.1007/s40618-015-0316-5

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