Skip to main content

Advertisement

SpringerLink
Log in

The association between lipid parameters and obesity in university students

  • Original Article
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

Background

Abdominal obesity is associated with high plasma triglyceride and with low plasma high-density lipoprotein cholesterol levels.

Aim and methods

Objective of the study was to find an association between plasma lipid and lipoprotein levels and anthropometric parameters in abdominal obesity in Slovakian university students. Lipid profile and anthropometric parameters of obesity were studied in a sample of 419 probands, including 137 men and 282 women.

Results

Males had higher values of non-high-density lipoprotein cholesterol (non-HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and very low-density lipoprotein cholesterol (VLDL-C) than females, but these differences were not significant. Females had significantly (P < 0.05) higher TC and HDL-C (P < 0.001) than males. In comparison, all anthropometric parameters in the males were significantly (P < 0.001) higher than in the females. A positive correlation between non-HDL-C, TG, VLDL-C and anthropometric parameters (BMI, WC, WHR, WHtR) was found at P < 0.001. LDL was positively correlated with BMI, WCF, WHtR and TC with BMI, WHtR at P < 0.001. We also observed a correlation between TC–WCF and LDL–WHR at P < 0.01. A negative correlation was found between HDL and all monitored anthropometric parameters at P < 0.001. On the other hand, no correlation between TC and WHR was detected.

Conclusion

This study shows an association between plasma lipid and lipoprotein levels and anthropometric parameters in abdominal obesity in young people, predominantly university students.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Dallmeier D, Koenig W (2014) Strategies for vascular disease prevention: the role of lipids and related markers including apolipoproteins, low-density lipoproteins (LDL)-particle size, high sensitivity C-reactive protein (hs-CRP), lipoprotein-associated phospholipase A2 (Lp-PLA2) and lipoprotein(a) (Lp(a)). Best Pract Res Clin Endocrinol Metab 28:281–294

    Article  CAS  PubMed  Google Scholar 

  2. Castelli W (1998) Lipoproteins and cardiovascular disease: biological basis and epidemiological studies. Value Health 1:105–109

    Article  CAS  PubMed  Google Scholar 

  3. Szczygielska A, Widomska S, Jaraszkiewicz M et al (2003) Blood lipids profile in obese or overweight patients. Ann Univ Mariae Curie Sklodowska Med 58:343–349

    PubMed  Google Scholar 

  4. Hubert H, Feinlieb M, McNamara P et al (1983) Obesity as an Independent risk factor for cardiovascular disease: a 26-year follow up of participants in the Framingham heart study. Circulation 67:968–977

    Article  CAS  PubMed  Google Scholar 

  5. Lew E (1985) Mortality and weight: insured lives and the American Cancer Society Studies. An Intern Med 103:1024–1029

    Article  CAS  Google Scholar 

  6. Lenz M, Richter T, Mühlhauser I (2009) The morbidity and mortality associated with overweight and obesity in adulthood. Dtsch Arztebl Int 106:641–648

    PubMed  PubMed Central  Google Scholar 

  7. Sherpa LY, Deji et al (2011) Lipid profile and its association with risk factors for coronary heart disease in the highlanders of Lhasa, Tibet. High Alt Med Biol 12:57–63

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Krahulec B (2005) Obezita a niektoré faktory prostredia podporujúce vznik metabolického syndrómu. Cardiol 14:161–165

    Google Scholar 

  9. Katzmarzyk PT, Reeder BA, Elliott S et al (2012) Body mass index and risk of cardiovascular disease, cancer and all-cause mortality. Public Health 103:147–151

    Google Scholar 

  10. Capuano V, Bambacaro A, D’Arminio T et al (2003) Correlation between body mass index and others risk factors for cardiovascular disease in women compared with men. Arch Chest Dis 60:295–300

    Google Scholar 

  11. Zhu SK, Wang ZM, Heshka S et al (2002) Waist circumference and obesity-associated risk factors among whites in the third National Health and Nutrition Examination Survey: clinical action thresholds. Am J Clin Nutr 76:743–749

    CAS  PubMed  Google Scholar 

  12. Janssen I, Katzmarzyk PT, Ross R (2004) Waist circumference and not body mass index explains obesity-related health risk. Am J Clin Nutr 79:379–384

    CAS  PubMed  Google Scholar 

  13. Lean ME, Han TS, Morrison CE (1995) Waist circumference as a measure for indicating need for weight management. BMJ 311:158–161

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Czernichow S, Kengne AP, Huxley RR, ADVANCE Collaborative Group et al (2011) Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE. Eur J Cardiovasc Prev Rehabil 18:312–319

    Article  PubMed  PubMed Central  Google Scholar 

  15. Browning LM, Hsieh SD, Ashwell M (2010) A systematic review of waist-to-height ratio as a screening tool for the prediction of cardiovascular disease and diabetes: 0.5 could be a suitable global boundary value. Nutr Res Rev 23:247–269

    Article  PubMed  Google Scholar 

  16. Bhatti MS, Akbri MZ, Shakoor M (2001) Lipid profile in obesity. J Ayub Med Coll Abbottabad 13:31–33

    CAS  PubMed  Google Scholar 

  17. Kelishadi R, Hashemipour M, Sheikh-Heidar A, Ghatreh-Samani S (2012) Changes in serum lipid profile of obese or overweight children and adolescents following a lifestyle modification course. ARYA Atherosclerosis J 8:143–148

    Google Scholar 

  18. Hutton B, Fergusson D (2004) Changes in body weight and serum lipid profile in obese patients treated with orlistat in addition to a hypocaloric diet: a systematic review of randomized clinical trials. Am J Clin Nutr 80:1461–1468

    CAS  PubMed  Google Scholar 

  19. Ugwuja EI, Ogbonna NC, Nwibo AN et al (2013) Overweight and obesity, lipid profile and atherogenic indices among civil servants in Abakalili, South Eastern Nigeria. Ann Med Health Sci Res 3:13–18

    Article  PubMed  PubMed Central  Google Scholar 

  20. Plourde G (2002) Impact of obesity on glucose and lipid profiles in adolescents at different age groups in relation to adulthood. BMC Family Pract 3:1–14

    Article  Google Scholar 

  21. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502

    CAS  PubMed  Google Scholar 

  22. Lohman TG, Roche AF, Martello R (1988) Anthropometric standardization reference manual. Human Kinetics, Champaign

    Google Scholar 

  23. Wilson PWF, Castelli WP, Kannel WB (1987) Coronary risk prediction in adults (the Framingham Heart Study). Am J Cardiol 59:91G–94G

    Article  CAS  PubMed  Google Scholar 

  24. Turner RC, Millns H, Neil HAW et al (1998) Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: united Kingdom Prospective Diabetes Study (UKPDS 23). BMJ 316:823–828

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Knopp RH (1990) Effects of sex steroid hormones on lipoprotein levels in pre- and post menopausal women. Can J Cardiol 6:31B–35B

    PubMed  Google Scholar 

  26. De Marinis E, Martini Ch, Trentalance A et al (2008) Sex differences in hepatic regulation of cholesterol homeostasis. J Endokrinol 198:635–643

    Article  Google Scholar 

  27. Dalton M, Cameron AJ, Zimmet PZ, AusDiab Steering Committee et al (2003) Waist circumference, waist-hip ratio and body mass index and their correlation with cardiovascular disease risk factors in Australian adults. J Intern Med 254:555–563

    Article  CAS  PubMed  Google Scholar 

  28. Goldstein JM, Jerram M, Abbs B et al (2010) Sex differences in stress response circuitry activation dependent on female hormonal cycle. J Neurosci 30:431–438

    Article  PubMed  PubMed Central  Google Scholar 

  29. Ashwell M, Gunn P, Gibson S (2012) Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: systematic review and meta-analysis. Obes Rev 13:275–286

    Article  CAS  PubMed  Google Scholar 

  30. Pouliot MC, Després JP, Lemieux S et al (1994) Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol 73:460–468

    Article  CAS  PubMed  Google Scholar 

  31. Després JP, Lemieux S, Lamarche B et al (1995) The insulin resistance-dyslipidemic syndrome: contribution of visceral obesity and therapeutic implications. Int J Obes Relat Metab Disord 1:76–86

    Google Scholar 

  32. Björntorp P (1996) The regulation of adipose tissue distribution in humans. Int J Obes Relat Metab Disord 20:291–302

    PubMed  Google Scholar 

  33. Jeong SK, Seo MW, Kim YH et al (2005) Does waist indicate dyslipidemia better than BMI in Korean adult population? J Korean Med Sci 20:7–12

    Article  PubMed  PubMed Central  Google Scholar 

  34. Ebbert JO, Jensen MD (2013) Fat depots, free fatty acids, and dyslipidemia. Nutrients 5:498–508

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Eisenberg S (1987) Lipoprotein abnormalities in hypertriglyceridemia: significance in atherosclerosis. Am Heart J 113:555–561

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported by the grant of the European Regional Development Fund—Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123), the project ED2.1.00/03.0076 from European Regional Development Fund and the Charles University Research Fund (Project Number P36), and by the Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic for the Structural Funds of the European Union (Projects No. ITMS26220220185, No. ITMS26220220104).

Conflict of interest

Authors declare no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Experimental Medicine, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovak Republic

    Z. Hertelyova, R. Salaj & A. Chmelarova

  2. Department of Pathophysiology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovak Republic

    P. Dombrovsky

  3. Department of Physiology, Faculty of Medicine in Pilsen, Charles University in Prague, Plzen, Czech Republic

    M. C. Dvorakova

  4. Biomedical Centre, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic

    M. C. Dvorakova

  5. Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne’s University Hospital and Masaryk University, Pekarska 53, 656 91, Brno, Czech Republic

    P. Kruzliak

Authors
  1. Z. Hertelyova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Salaj
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Chmelarova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Dombrovsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. C. Dvorakova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P. Kruzliak
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. Kruzliak.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hertelyova, Z., Salaj, R., Chmelarova, A. et al. The association between lipid parameters and obesity in university students. J Endocrinol Invest 39, 769–778 (2016). https://doi.org/10.1007/s40618-015-0240-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40618-015-0240-8

Keywords

Search

Navigation