Toward a physiological referent for the vitamin D requirement
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Current approaches to setting nutrient intake recommendations are based in a disease-prevention paradigm. The disease to be prevented is typically the disorder classically associated with the nutrient concerned: scurvy for vitamin C, polyneuritis for thiamine, bone disease for vitamin D (D). And the method used is the randomized, controlled trial. While there is growing recognition that nutrients affect many systems, the disease-prevention approach continues, in most cases, to focus on one, or at most two, body systems. For D (cholecalciferol), that system is the skeleton .
In contrast, there is general recognition that most nutrients, particularly the micro-nutrients, function to sustain health basically at a molecular-biological level. Logically, the criteria for setting intake requirements should be based on the actual function of the nutrients concerned, not on diseases that they might arguably prevent. In other words, intake recommendations should be based in physiology.
KeywordsCholecalciferol Human Milk Scurvy Intake Recommendation Increase Calcium Absorption
Conflict of interest
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