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Associations between the GNB3 C825T polymorphism and obesity-related metabolic risk factors in Korean obese women

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Abstract

Purpose

It is important to identify a ‘metabolically unhealthy obese’ subset with higher cardiovascular risk among obese individuals. We investigated the associations between the GNB3 C825T polymorphism and obesity-related metabolic risk factors among Korean obese women.

Methods

This study was a sub-investigation of a double-blind randomized controlled trial that examined the additive effect of or list at on weight loss with sibutramine. A sample of 111 obese women were divided into T-carriers (CT/TT) or a homozygous CC group, according to the presence of the 825T allele at GNB3. These groups were compared to determine their associations with obesity-related metabolic risk factors, i.e., fasting plasma glucose, serum lipids, serum insulin/insulin resistance, and abdominal fat amounts.

Results

The allele frequencies of the GNB3 polymorphism were C allele = 59.5 % and T allele = 40.5 %. The T allele was found to be significantly associated with greater visceral fat and higher serum lipids, and these significances remained robust after adjusting for potential covariates.

Conclusions

The GNB3 825T polymorphism is significantly associated with greater visceral fat and higher serum lipids in Korean obese women and it suggests that the GNB3 C825T is a determinant of obesity-related metabolic traits in this population.

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Abbreviations

WC:

Waist circumference

SNP:

Single nucleotide polymorphism

GNB3:

Guanine nucleotide-binding protein beta 3 subunit

BMI:

Body mass index

TG:

Triglyceride

CT:

Computed tomography

LDL-C:

Low-density lipoprotein cholesterol

PCR:

Polymerase chain reaction

References

  1. Sims EA (2001) Are there persons who are obese, but metabolically healthy? Metabolism 50:1499–1504

    Article  PubMed  CAS  Google Scholar 

  2. Ortega FB, Lee DC, Katzmarzyk PT et al (2013) The intriguing metabolically healthy but obese phenotype: cardiovascular prognosis and role of fitness. Eur Heart J34:389–397

    Article  Google Scholar 

  3. Padwal RS, Pajewski NM, Allison DB, Sharma AM (2011) Using the Edmonton obesity staging system to predict mortality in a population-representative cohort of people with overweight and obesity. CMAJ 183:1059–1066

    Article  Google Scholar 

  4. Joy T, Lahiry P, Pollex RL, Hegele RA (2008) Genetics of metabolic syndrome. Curr Diab Rep 8:141–148

    Article  PubMed  CAS  Google Scholar 

  5. Regard JB, Sato IT, Coughlin SR (2008) Anatomical profiling of G protein-coupled receptor expression. Cell 135:561–571

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  6. Hsiao TJ, Hwang Y, Liu CH, Chang HM, Lin E (2013) Association of the C825T polymorphism in the GNB3 gene with obesity and metabolic phenotypes in a Taiwanese population. Genes Nutr 8:137–144

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  7. Wascher TC, Paulweber B, Malaimare L et al (2003) Associations of a human G protein Beta3 subunit dimorphism with insulin resistance and carotid atherosclerosis. Stroke 34:605–609

  8. Nürnberger J, Dammer S, Philipp T, Wenzel RR, Schafers RF (2003) Metabolic and haemodynamic effects of oral glucose loading in young healthy men carrying the 825T-allele of the G protein β3 subunit. Cardiovasc Diabetol 2:7

    Article  PubMed  PubMed Central  Google Scholar 

  9. Hwang IC, Park JY, Ahn HY et al (2014) Effects of CYP3A5, CYP2C19, and CYP2B6 on the clinical efficacy and adverse outcomes of sibutramine therapy: a crucial role for the CYP2B6*6 allele. Clin Chim Acta 428:77–81

    Article  PubMed  CAS  Google Scholar 

  10. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419

    Article  PubMed  CAS  Google Scholar 

  11. Lee JY, Kim SU, Cho JK, Woo SK, Kang HS (2009) GNB3 C825T polymorphism and elevated blood pressure. Int J Sports Med 30:892–897

    Article  PubMed  CAS  Google Scholar 

  12. Arner P (1999) Catecholamine-induced lipolysis in obesity. Int J Obes Relat Metab Disord 23 Suppl 1:10–13

  13. Ryden M, Faulds G, Hoffstedt J, Wennlund A, Arner P (2002) Effect of the (C825T) Gbeta(3) polymorphism on adrenoceptor-mediated lipolysis in human fat cells. Diabetes 51:1601–1608

    Article  PubMed  CAS  Google Scholar 

  14. Jocken JW, Blaak EE, Schiffelers S (2007) Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation. Int J Obes (Lond) 31:813–819

  15. NicholsonAC HajjarDP (1992) Transforming growth factor-beta up-regulates low density lipoprotein receptor-mediated cholesterol metabolism in vascular smooth muscle cells. J Biol Chem 267:25982–25987

    Google Scholar 

  16. VijayagopalP SrinivasanSR, RadhakrishnamurthyB Berenson GS (1991) Studies on the mechanism of uptake of low density lipoprotein-proteoglycan complex in macrophages. Biochem Biophys Acta 1092:291–297

    Article  Google Scholar 

  17. Ishikawa K, Imai Y, Katsuya T et al (2000) Human G-protein beta3 subunit variant is associated with serum potassium and total cholesterol levels but not with blood pressure. Am J Hypertens 13:140–145

    Article  PubMed  CAS  Google Scholar 

  18. Andersen G, Overgaard J, Albrechtsen A et al (2006) Studies of the association of the GNB3 825C > T poly-morphism with components of the metabolic syndrome in white Danes. Diabetologia 49:75–82

    Article  PubMed  CAS  Google Scholar 

  19. Stefan N, Stumvoll M, Machicao F et al (2004) C825T polymorphism of the G protein beta3 subunit is associated with obesity but not with insulin sensitivity. Obes Res 12:679–683

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The original clinical trial (NCT01184560) was funded by Hanmi Pharmaceuticals, Ltd., Seoul, Korea.

Conflict of interest

The authors have no conflicts of interest.

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Authors and Affiliations

  1. Department of Family Medicine, Gachon University Gil Medical Center, 1198 Guwol-dong, Namdong-gu, Incheon, 405-760, Republic of Korea

    K. D. Ko, K. K. Kim, H. S. Suh & I. C. Hwang

Authors
  1. K. D. Ko
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  2. K. K. Kim
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  3. H. S. Suh
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  4. I. C. Hwang
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Corresponding author

Correspondence to I. C. Hwang.

Additional information

K. D. Ko and K. K. Kim contributed equally to this work.

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Ko, K.D., Kim, K.K., Suh, H.S. et al. Associations between the GNB3 C825T polymorphism and obesity-related metabolic risk factors in Korean obese women. J Endocrinol Invest 37, 1117–1120 (2014). https://doi.org/10.1007/s40618-014-0182-6

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  • DOI: https://doi.org/10.1007/s40618-014-0182-6

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