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Serum 25 hydroxyvitamin D in employees of a Middle Eastern university hospital

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Abstract

Background

The Middle East registers the highest rate of vitamin D deficiency worldwide. In Lebanon, previous studies looked at this deficiency in schoolchildren, university students, young adults and postmenopausal women. However, no previous study was performed in hospital workers. The objective of our study was to evaluate vitamin D status in a Beirut hospital center and to look at the potential factors influencing these measurements.

Methods

This cross-sectional study was performed on hospital employees who came for a regular checkup at the primary health-care department. 25(OH)D measurements were performed using the Dia-Sorin chemiluminescent assay.

Results

392 subjects (318 women and 74 men) were included in the study. The mean age of the participants was 41.02 ± 11.3 years. The mean 25(OH)D level was 15.61 ± 7.91 ng/ml, with no significant difference according to gender. There were no significant correlations between 25(OH)D and both BMI and age, but 25(OH)D was significantly associated with educational level (p = 0.03). There was a significant difference in 25(OH)D levels according to season (p < 0.001) and a significant association between 25(OH)D and the reported weekly hours of sun exposure (r = 0.1, p = 0.032), but not with the reported sunscreen use. Fish consumption was positively associated with 25(OH)D levels (p = 0.018), while milk, dairy product or egg consumption did not achieve any significant relationship. In a stepwise linear regression analysis, fish consumption and season were the only independent predictors of 25(OH)D levels (p = 0.007 and p = 0.0001 respectively).

Conclusion

Vitamin D deficiency is common among hospital workers. This finding reinforces the need for vitamin D supplementation in these high-risk populations.

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References

  1. Holick MF (2007) Vitamin D deficiency. New Eng J Med 357:266–281

    Article  CAS  PubMed  Google Scholar 

  2. Holick MF (2006) High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 81:353–373

    Article  CAS  PubMed  Google Scholar 

  3. Holick MF, Chen TC (2008) Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87:1080S–1086S

    CAS  PubMed  Google Scholar 

  4. Lowdon J (2008) Low vitamin D status: on the increase? J Fam Health Care 18:55–57

    PubMed  Google Scholar 

  5. Mithal A, Wahl DA, Bonjour JP et al (2009) IOF Committee of Scientific Advisors (CSA) Nutrition Working Group. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 20:1807–1820

    Article  CAS  PubMed  Google Scholar 

  6. Wahl DA, Cooper C, Ebeling PR et al (2012) A global representation of vitamin D status in healthy populations. Arch Osteoporos 7:155–172

    Article  CAS  PubMed  Google Scholar 

  7. Lips P, Hosking D, Lippuner K et al (2006) The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation. J Intern Med 260:245–254

    Article  CAS  PubMed  Google Scholar 

  8. Baroncelli GI, Bereket A, El Kholy M et al (2008) Rickets in the Middle East: role of environment and genetic predisposition. J Clin Endocrinol Metab 93:1743–1750

    Article  CAS  PubMed  Google Scholar 

  9. Fuleihan G El-Hajj, Nabulsi M, Choucair M et al (2001) Hypovitaminosis D in healthy schoolchildren. Pediatrics 107:E53

    Article  Google Scholar 

  10. Gannagé-Yared MH, Chedid R, Khalifé S, Azzi E, Zoghbi F, Halaby G (2009) Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population. Eur J Endocrinol 160:965–971

    Article  PubMed  Google Scholar 

  11. Gannagé-Yared MH, Chemali R, Yaacoub N, Halaby G (2000) Hypovitaminosis D in a sunny country relation to lifestyle and bone markers. J Bone Mine Res 15:1856–1862

    Article  Google Scholar 

  12. Gannagé-Yared MH, Maalouf G, Khalifé S, Challita S, Yaghi Y, Ziadé N (2009) Prevalence and predictors of vitamin D inadequacy among Lebanese osteoporotic women. Br J Nutr 101:487–491

    Article  PubMed  Google Scholar 

  13. Mendell MJ, Fisk WJ, Kreiss K et al (2002) Improving the health of workers in indoor environments: priority research needs for a national occupational research agenda. Am J Public Health 92:1430–1440

    Article  PubMed Central  PubMed  Google Scholar 

  14. Holick MF (2003) Vitamin D: a millenium perspective. J Cell Biochem 88:296–300

    Article  CAS  PubMed  Google Scholar 

  15. Sullivan SS, Rosen CJ, Halteman WA, Chen TC, Holick MF (2005) Adolescent girls in Maine are at risk for vitamin D insufficiency. J Am Diet Assoc 105:971–974

    Article  CAS  PubMed  Google Scholar 

  16. Growdon AS, Camargo CA Jr, Clark S, Hannon M, Mansbach JM (2012) Serum 25-hydroxyvitamin D levels among Boston trainee doctors in winter. Nutrients 4:197–207

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. González-Padilla E, Soria López A, González-Rodríguez E et al (2011) High prevalence of hypovitaminosis D in medical students in Gran Canaria, Canary Islands (Spain). Endocrinol Nutr 58:267–273

    Article  PubMed  Google Scholar 

  18. Multani SK, Sarathi V, Shivane V, Bandgar TR, Menon PS, Shah NS (2010) Study of bone mineral density in resident doctors working at a teaching hospital. J Postgrad Med 56:65–70

    Article  CAS  PubMed  Google Scholar 

  19. Al-Elq AH (2012) The status of Vitamin D in medical students in the preclerkship years of a Saudi medical school. J Family Community Med 19:100–104

    Article  PubMed Central  PubMed  Google Scholar 

  20. MacLaughlin J, Holick MF (1985) Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 76:1536–1538

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  21. Mitchell DM, Henao MP, Finkelstein JS, Burnett-Bowie SA (2012) Prevalence and predictors of vitamin D deficiency in healthy adults. Endocr Pract 18:914–923

    Article  PubMed Central  PubMed  Google Scholar 

  22. Gagnon C, Baillargeon JP, Desmarais G, Fink GD (2010) Prevalence and predictors of vitamin D insufficiency in women of reproductive age living in northern latitude. Eur J Endocrinol 163:19–24

    Article  Google Scholar 

  23. Maeda SS, Saraiva GL, Kunii IS et al (2013) Factors affecting vitamin D status in different populations in the city Sao Paulo, Brazil: the Sao PAulo vitamin D Evaluation Study (SPADES). BMC Endocr Disord 13:14

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Worstman J, Matsuoka LY, Chen TC, Lu Z, Holick MF (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72:690–693

    Google Scholar 

  25. Saneei P, Salehi-Abargouei A, Esmaillzadeh A (2013) Serum 25-hydroxy vitamin D levels in relation to body mass index: a systematic review and meta-analysis. Obes Rev 14:393–404

    Article  CAS  PubMed  Google Scholar 

  26. Bassil D, Rahme M, Hoteit M, Gel-H Fuleihan (2013) Hypovitaminosis D in the Middle East and North Africa: prevalence, risk factors and impact on outcomes. Dermatoendocrinol 5:274–298

    Article  PubMed Central  PubMed  Google Scholar 

  27. McCarty CA (2008) Sunlight exposure assessment: can we accurately assess vitamin D exposure from sunlight questionnaires? Am J Clin Nutr 87:1097S–1101S

    CAS  PubMed  Google Scholar 

  28. Matsuoka LY, Ide L, Wortsman J, MacLaughlin JA, Holick MF (1987) Sunscreens suppress cutaneous vitamin D3 synthesis. J Clin Endocrinol Metab 64:1165–1168

    Article  CAS  PubMed  Google Scholar 

  29. Marks R, Foley PA, Jolley D, Knight KR, Harrison J, Thompson SC (1995) The effect of regular sunscreen use on vitamin D levels in an Australian population. Results of a randomized controlled trial. Arch Dermatol 131:415–421

    Article  CAS  PubMed  Google Scholar 

  30. Farrerons J, Barnadas M, Rodriguez J et al (1998) Clinically prescribed sunscreen (sun protection factor 15) does not decrease serum vitamin D concentration sufficiently either to induce changes in parathyroid function or in metabolic markers. Br J Dermatol 139:422–427

    Article  CAS  PubMed  Google Scholar 

  31. Yu A, Kim J, Kwon O, Oh SY, Kim J, Yang YJ (2013) The association between serum 25-hydroxyvitamin D concentration and consumption frequencies of vitamin d food sources in Korean adolescents. Clin Nutr Res 2:107–114

    Article  PubMed Central  PubMed  Google Scholar 

  32. Reis JP, Von Muhlen D, Miller ER (2008) Relation of 25-hydroxyvitamin D and parathyroid hormone levels with metabolic syndrome among US adults. Eur J Endocrinol 159:41–48

    Article  CAS  PubMed  Google Scholar 

  33. Holick MF, Binkley NC, Bischoff-Ferrari et al (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 96:1911–1930

    Article  CAS  PubMed  Google Scholar 

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Conflict of interest

The authors declare that they have no financial competing interests.

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Authors and Affiliations

  1. Department of Endocrinology, Hotel-Dieu de France Hospital, Saint-Joseph University, Beirut, Lebanon

    M.-H. Gannagé-Yared, E. Helou, V. Zaraket, S. Abi Akl, L. Antonios & M.-L. Moussalli

  2. Department of Employees Primary Health Care, Hôtel Dieu de France Hospital, Beirut, Lebanon

    S. Wakim

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  1. M.-H. Gannagé-Yared
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  2. E. Helou
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  3. V. Zaraket
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  4. S. Abi Akl
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  6. M.-L. Moussalli
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Correspondence to M.-H. Gannagé-Yared.

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Gannagé-Yared, MH., Helou, E., Zaraket, V. et al. Serum 25 hydroxyvitamin D in employees of a Middle Eastern university hospital. J Endocrinol Invest 37, 541–546 (2014). https://doi.org/10.1007/s40618-014-0061-1

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  • DOI: https://doi.org/10.1007/s40618-014-0061-1

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