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Normative reference of short-term heart rate variability and estimation of cardiovascular autonomic neuropathy prevalence in Chinese people

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Abstract

Background

The cardiovascular autonomic neuropathy (CAN) prevalence is rapidly growing in all populations worldwide. This study aimed to evaluate the reference values for the short-term heart rate variable (HRV) and estimate CAN prevalence in our cross-sectional dataset.

Methods

We conducted a large-scale, community-based, cross-sectional study in a Chinese population. Of 2,092 subjects available for data analysis, 371 healthy subjects were selected to reference the values for the short-term HRV. The short-term HRV analysis was performed for all subjects using a computer-aided examination and evaluation system for spectral analysis to investigate changes in autonomic regulation.

Results

In the total sample, the reference value for total power was more than 356.13 ms2. The cutoff points of 55.45 and 36.64 ms2 were set for low frequency (LF) and high frequency (HF), respectively. The cutoff points of LFn and HFn were 6.40 and 4.83 ν, respectively. The normative reference of LF/HF ranged from 0.3 to 6.5. Using HRV test (model 1), the estimated age-adjusted CAN prevalence in the total sample was 16.83 %. The estimated age-adjusted CAN prevalence values were 31.07, 21.97 and 20.81 % in DM, HT, and MS patients, respectively.

Conclusion

Our findings provided reference values for short-term HRV. The estimated CAN prevalence was high in the Chinese population.

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Abbreviations

BP:

Blood pressure

BMI:

Body mass index

CAN:

Cardiovascular autonomic neuropathy

CI:

Credible intervals

Cr:

Creatinine

DM:

Diabetes

FPG:

Fasting plasma glucose

HDL:

High-density lipoprotein cholesterol

HF:

High frequency

HRV:

Heart rate variability

LDL:

Low-density lipoprotein cholesterol

LF:

Low frequency

MS:

Metabolic syndrome

K–S:

Kolmogorov–Smirnov

OGTT:

Oral glucose tolerance test

PBG:

Postprandial blood glucose

HT:

Hypertension

TC:

Serum total cholesterol

TG:

Triglyceride

WC:

Waist circumference

UA:

Uric acid

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Acknowledgments

We thank the support granted from China National Grant on Science and Technology to support the study (grant number: 30570740).

Conflict of interest

F. Zeng, Z.-H. Tang, Z. Li, X. Yu and L. Zhou declare they have no conflict of interest.

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Authors and Affiliations

  1. Departments of Endocrinology and Metabolism, Huashan Hospital of Fudan University, NO. 12 Wulumuqi Mid Road, Building 0#, Jing’an District, Shanghai, 200040, China

    F. Zeng, Z.-H. Tang, Z. Li, X. Yu & L. Zhou

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  1. F. Zeng
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  2. Z.-H. Tang
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  3. Z. Li
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  4. X. Yu
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  5. L. Zhou
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Corresponding author

Correspondence to Z.-H. Tang.

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Zeng, F., Tang, ZH., Li, Z. et al. Normative reference of short-term heart rate variability and estimation of cardiovascular autonomic neuropathy prevalence in Chinese people. J Endocrinol Invest 37, 385–391 (2014). https://doi.org/10.1007/s40618-013-0047-4

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  • DOI: https://doi.org/10.1007/s40618-013-0047-4

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