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Low Hospital Volume Is Associated with Higher All-Cause Mortality in Black Women with Triple Negative Breast Cancer

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Abstract

Introduction

This study examines the association between hospital volume and all-cause mortality in Black women with triple negative breast cancer (TNBC) who received surgery and chemotherapy.

Methods

Black women ages 18+ with stage I-III TNBC who received both surgery and chemotherapy were identified in the National Cancer Database (NCDB). Hospital volume was determined using the number of annual breast cancer cases divided by the number of years the hospital participated in the NCDB. Hospital annual volume quartiles ranged from Q1 (lowest) to Q4 (highest). Univariable analysis and multivariable logistic regression modeling with restricted cubic splines examined the effect of hospital volume on all-cause mortality.

Results

Sixteen thousand five hundred fifty-six patients met the study criteria. All-cause mortality incidence was lower at higher volume compared to lower volume hospitals Q1 24.1% (95% CI: 22.8 to 25.4), Q2 21.8% (95% CI: 20.5 to 23.1), Q3 20.9% (95% CI: 19.6 to 22.1), Q4 19.0% (95% CI: 17.7 to 20.1), p<0.001. On multivariable analysis, treatment at the highest hospital volume quartile was associated with a 21% reduction in the odds of death compared to the lowest quartile [Q4 Vs. Q1, OR=0.79 (95% CI: 0.67 to 0.92)]. For every 100-patient increase in annual volume, all-cause mortality was reduced by 4% [OR=0.96 (95% CI: 0.94 to 0.98)]. There was a significant linear dose-dependent relationship between increasing hospital volume and all-cause mortality.

Conclusion

Black women treated at high-volume hospitals have lower all-cause mortality than those at low-volume hospitals. Future studies should examine the characteristics of high-volume hospitals associated with improved outcomes.

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Funding

This project is funded by The Ohio State University Comprehensive Cancer Center Pelotonia Grant. Samilia Obeng-Gyasi is funded by the Paul Calabresi Career Development Award (K12 CA133250), Conquer Cancer Breast Cancer Research Foundation Advanced Clinical Research Award for Diversity and Inclusion in Breast Cancer Research, The Society of University Surgeons, and The American Cancer Society (RSG-22-106-01-CSCT).

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Authors

Contributions

Samilia Obeng-Gyasi, Demond Handley, Mohamed I. Elsaid, Saurabh Rahurkar, Barbara L. Andersen, Pallavi Jonnalagadda, Nicci Owusu-Brackett, William E Carson, JC Chen, and Daniel Stover made contributions to conceptualization, data curation, formal analysis, investigation, writing the original draft and review and editing subsequent drafts. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Samilia Obeng-Gyasi.

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Ethics Approval

The Ohio State University Office of Responsible Research Practices deemed this study IRB exempt.

Consent to Participate

This study is IRB exempt therefore individual consent for this retrospective review was waived.

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This study is IRB exempt therefore individual consent to publish for this retrospective review was waived.

Disclosure

The National Cancer Database (NCDB) is a joint project of the Commission on Cancer (CoC) of the American College of Surgeons and the American Cancer Society. The CoC’s NCDB and the hospitals participating in the CoC’s NCDB are the source of the de-identified data used herein; they have not verified and are not responsible for the statistical validity of the data analysis or the conclusions derived by the authors.

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The authors declare no competing interests.

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Obeng-Gyasi, S., Handley, D., Elsaid, M.I. et al. Low Hospital Volume Is Associated with Higher All-Cause Mortality in Black Women with Triple Negative Breast Cancer. J. Racial and Ethnic Health Disparities (2023). https://doi.org/10.1007/s40615-023-01788-y

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