Abstract
Objective
Research that assesses the relationship between psychosocial factors and chronic kidney disease (CKD) among African Americans (AAs) is limited. Using the Jackson Heart Study (JHS) cohort data, we investigated the association of goal-striving stress (GSS)—the stress experienced from not reaching goals—with prevalent CKD among AAs.
Design
This was a cross-sectional analysis of JHS exam 1 data that assessed the relationship between GSS and CKD.
Setting and Participants
We utilized a sample from the JHS (n = 4967), an AA sample of women and men, 35–84 years old from the Jackson, MS metro area.
Main Outcome Measures
The baseline relationship between GSS levels (low, moderate, and high) and CKD (eGFR < 60 mL/min/1.73m2) was evaluated using a logistic regression model to estimate odds ratios (OR) on a 95% confidence interval (CI). The final model was adjusted for sex, age, socioeconomic status, health behaviors, risk factors, and total stress.
Results
After full adjustment, the odds of prevalent CKD increased by 52% (OR 1.52; 95% CI 1.04, 2.24) for those reporting high (versus low) GSS.
Conclusions
Deficiencies between goal aspiration and achievement were associated with prevalent CKD. Potential interventions might consider the impact GSS contributes to prevalent CKD.
Similar content being viewed by others
References
Centers for Disease Control and Prevention. National Chronic Disease Fact Sheet, 2017. https://www.cdc.gov/diabetes/pubs/pdf/kidney_factsheet.pdf. Accessed December 6, 2017.
Mozaffarian D, Benjamin E, Go A, et al. Heart Disease and Stroke Statistics—2016 update: a report From the American Heart Association. Circulation. 2016;133(4):e38–360.
Seeman T, Mcewan B. Impact of social environment characteristics on neuroendocrine regulation. Psychosom Med. 1996;58(5):459–71.
Cohen S, Herbert T. Health psychology: psychological factors and physical disease from the perspective of human psychoneuroimmunology. Annu Rev. Psychol. 1996;47:113–42.
Bruce M, Griffith D, Thorpe RJ. Stress and the kidney. Adv Chronic Kidney Dis. 2015;1:46–53.
Norton J, Moxey-Mims M, Eggers P, et al. Social determinants of racial disparities in CKD. J Am Soc Nephrol. 2016;27(9):2576–95.
Kimmel P, Cohen S, Peterson R. Depression in patients with chronic renal disease: where are we going? J Ren Nutr. 2008;18(1):99–103.
Cukor D, Coplan J, Brown C, et al. Anxiety disorders in adults treated by hemodialysis: a single-center study. Am J Kidney Dis. 2008;52(1):128–36.
Levy N. Psychonephrology 2: Psychological problems in kidney failure and their treatment. New York: Plenum Medical Book Company; 1983.
Neighbors H, Sellers S, Zhang R, et al. Goal-striving stress and racial differences in mental health. Race Social Problems. 2011;3(1):51–62.
Mendez D, Hogan V, Culhane J. Institutional racism and pregnancy health: using Home Mortgage Disclosure Act data to develop an index for mortgage discrimination at the community level. Publ Health Rep. 2011;126(Suppl 3):102–14.
Isaacs J, Sawhil l, Haskins R Getting ahead or losing ground: economic mobility in America. 2008. https://www.brookings.edu/research/getting-ahead-or-losing-ground-economic-mobility-in-america/. Accessed December 6, 2017.
Bruce M, Beech B, Sims M, et al. Social environmental stressors, psychological factors, and kidney disease. J Investig Med. 2009;57(4):583–9.
Everson-Rose S, Lewis T. Psychosocial factors and cardiovascular diseases. Annu Rev. Public Health. 2005;26:469–500.
Sellers SL, Neighbors HW, Zhang R, Jackson JS. The impact of goal-striving stress on physical health of white Americans, African Americans, and Caribbean blacks. Ethn Dis. 2012 Winter;22(1):21–8.
Fuqua S, Wyatt S, Andrew M, et al. Recruiting African-American research participation in the Jackson Heart Study: methods, response rates, and sample description. Ethn Dis. 2005;15(4 Suppl 6):S6. –18-29
Taylor HJ, Wilson J, Jones D, et al. Toward resolution of cardiovascular health disparities in African Americans: design and methods of the Jackson Heart Study. Ethn Dis. 2005;15(4 Suppl 6):S6):4–17.
Levey A, Stevens L, Schmid C, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604–12.
Inker L, Schmid C, Tighiouart H, et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012;367(1):20–9.
Tangri N, Stevens L, Schmid C, et al. Changes in dietary protein intake has no effect on serum cystatin C levels independent of the glomerular filtration rate. Kidney Int. 2011;79(4):471–7.
Stevens L, Schmid C, Greene T, et al. Factors other than glomerular filtration rate affect serum cystatin C levels. Kidney Int. 2009;75(6):652–60.
Shlipak M, Sarnak M, Katz R, et al. Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med. 2005;352(20):2049–60.
Carpenter M, Crow R, Steffes M, et al. Laboratory, reading center, and coordinating center data management methods in the Jackson Heart Study. Am J Med Sci. 2004;328(3):131–44.
Wang W, Young B, Fülöp T, et al. Effects of serum creatinine calibration on estimated renal function in African Americans: the Jackson Heart Study. Am J Med Sci. 2015;349(5):379–84.
Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983;24(4):385–96.
Hedayati S, Minhajuddin A, Toto R, et al. Validation of depression screening scales in patients with CKD. Am J Kidney Dis. 2009;54(3):433–9.
Kessler R, Berglund P, Demler O, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003;289(23):3095–105.
Gholson G, Mwendwa D, Wright R, et al. The combined influence of psychological factors on biomarkers of renal functioning in African Americans. Ethn Dis. 2015;25(2):117–22.
Crews D, Pfaff T, Powe N. Socioeconomic factors and racial disparities in kidney disease outcomes. Seminars in Nephrology. 2013;33(5):468–75.
Brotman D, Golden S, Wittstein I. The cardiovascular toll of stress. Lancet. 2007;370(9592):1089–100.
Kooman J, Kotanko P, Schols AM, et al. Chronic kidney disease and premature ageing. Nat Rev. Nephrol. 2014;10(12):732–42.
Acknowledgements
We wish to thank all participants of the Jackson Heart Study for their time, effort, and dedication towards this study. The abstract was presented at the American Heart Association Scientific Sessions 2017 in Anaheim, CA.
Support
The Jackson Heart Study (JHS) is supported and conducted in collaboration with Jackson State University (HHSN268201300049C and HHSN268201300050C), Tougaloo College (HHSN268201300048C), and the University of Mississippi Medical Center (HHSN268201300046C and HHSN268201300047C) contracts from the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute on Minority Health and Health Disparities (NIMHD). Dr. Sims is supported by the grants P60MD002249 and (Ms. Glover) U54MD008176 from NIMHD; 15SFDRN26140001 and P50HL120163 from the American Heart Association. This study was also supported by Dr. Young’s National Institutes of Health (NIH) National Institute of Diabetes, Digestive, and Kidney Disease grant 1R01DK102134-01. Dr. Young is also supported, in part, by funding from the Veterans Affairs Puget Sound Health Care System.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Informed Consent
Informed consent was obtained from all individual participants included in the study.
Disclosures
The authors declare that they have no conflicts of interest.
Disclaimer
The Veterans Affairs does not endorse any of the statements or opinions advocated by this manuscript. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services. The funders had no role in the study design, collection, analysis, interpretation of data, writing the report, or the decision to submit the report for publication.
Rights and permissions
About this article
Cite this article
Cain, L.R., Glover, L., Young, B. et al. Goal-Striving Stress Is Associated with Chronic Kidney Disease Among Participants in the Jackson Heart Study. J. Racial and Ethnic Health Disparities 6, 64–69 (2019). https://doi.org/10.1007/s40615-018-0499-5
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40615-018-0499-5