Current Molecular Biology Reports

, Volume 4, Issue 1, pp 16–23 | Cite as

Molecular Differences Between Subtypes of Bone Marrow Adipocytes

  • Clarissa S Craft
  • Ziru Li
  • Ormond A MacDougald
  • Erica L Scheller
Molecular Biology of Bone Marrow Fat Adiposity (B van der Eerden, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Molecular Biology of Bone Marrow Fat Adiposity


Purpose of Review

Bone marrow adipocytes (BMAs) have distinct molecular properties and physiologic responses depending on their location within the skeleton.

Recent Findings

This concept was introduced in the 1970s and validated more recently in the contexts of cold exposure, sympathetic tone, hematopoiesis, diabetes, lactation, fasting, and caloric restriction.


In this brief review, we discuss the concept of regulated vs constitutive BMAs, explore their evolutionary and microenvironmental origins, define the site-specific molecular features of BMAs, and discuss the translational implications of the dual bone marrow adipose tissue hypothesis.


Bone marrow adipocyte Adipose Marrow fat Yellow marrow Hematopoiesis 


Funding Information

This work was funded by the National Institutes of Health including a pilot grant from the Washington University Musculoskeletal Research Center P30-AR057235 (C.S.C.), R24-DK092759 (O.A.M.), and R00-DE024178 (E.L.S.).

Compliance with Ethical Standards

Conflict of Interest

Clarissa S. Craft, Ziru Li, Ormond A. MacDougald, and Erica L. Scheller each declare no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Clarissa S Craft
    • 1
    • 2
  • Ziru Li
    • 3
  • Ormond A MacDougald
    • 3
  • Erica L Scheller
    • 1
    • 2
  1. 1.Division of Bone and Mineral Diseases, Department of Internal MedicineWashington UniversitySaint LouisUSA
  2. 2.Department of Cell Biology & PhysiologyWashington UniversitySt. LouisUSA
  3. 3.Department of Molecular & Integrative PhysiologyUniversity of MichiganAnn ArborUSA

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