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Omics Contributions to the Molecular Mechanisms Regulating Bone Marrow Adipocyte Differentiation

  • Molecular Biology of Bone Marrow Fat Adiposity (B van der Eerden, Section Editor)
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Abstract

Purpose of Review

A shift in the commitment of human skeletal stem cells (SSCs) from the osteogenic lineage to the adipogenic lineage can result in increased marrow adiposity and bone loss. Advances in understanding the fate decision of SSCs and particularly the intracellular mechanisms controlling bone marrow adipocyte (BMA) differentiation have thus relevance to bone disorders. The aim of this review is to report the recent contributions of Omics studies to the understanding of mechanisms controlling human BMA differentiation.

Recent Findings

Omics investigations allow the identification of factors involved in BMA differentiation, some of them already known to have relevance for adipogenesis and others not, and highlight the crucial role of epigenetic regulation in the control of SSCs lineage determination.

Summary

There is a great potential in the use of Omics technologies for a better understanding of BMA differentiation. To draw a more complete picture of this process, efforts must be made in the standardization, compilation, and integration of data from different fields. Further expected outcome is the future identification of biomarkers or therapeutic targets in the context of bone disorders.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. Université de Lille, EA 4490, PMOI-Physiopathologie des Maladies Osseuses Inflammatoires, F-59000, Lille, France

    Aline Clabaut & Odile Broux

  2. ULCO, PMOI, F-62200, Boulogne-sur-mer, France

    Aline Clabaut & Odile Broux

  3. ULCO, PMOI, Bassin Napoléon, BP 120, F-62327, Boulogne-sur-Mer, France

    Odile Broux

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  1. Aline Clabaut
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  2. Odile Broux
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Correspondence to Odile Broux.

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This article is part of the Topical Collection on Molecular Biology of Bone Marrow Fat Adiposity

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Clabaut, A., Broux, O. Omics Contributions to the Molecular Mechanisms Regulating Bone Marrow Adipocyte Differentiation. Curr Mol Bio Rep 4, 1–7 (2018). https://doi.org/10.1007/s40610-018-0085-y

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