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Listeria monocytogenes Cancer Vaccines: Bridging Innate and Adaptive Immunity

  • Microbial Anti-cancer Therapy and Prevention (PJF Rider, L Sweeny, and KG Kousoulas, Section Editors)
  • Published:
Current Clinical Microbiology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Immunotherapy has emerged as a promising cancer treatment; however, success in only select clinical indications underscores the need for novel approaches. Recently Listeria monocytogenes–based vaccines have been developed to drive tumor-specific T cell responses. Here, we discuss recent preclinical studies using L. monocytogenes vaccines, innate immune pathways that influence T cell priming, and new vaccine strategies in clinical trials.

Recent Findings

Recent studies indicate that in addition to inducing antigen-specific T cell responses, L. monocytogenes vaccines remodel the TME. In addition, several innate immune pathways influence adaptive immune responses to L. monocytogenes and modulating these pathways holds promise to enhance antitumor T cell responses.

Summary

The interplay between innate and adaptive immune responses to L. monocytogenes is poorly understood. Understanding these interactions will facilitate the design of better anti-cancer vaccines and improved use of combination therapies.

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Funding

This study was supported by grant R01 CA188034 from the National Institutes of Health (JDS). In addition, this material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program (Z.T.M) under Grant No. DGE-1747503. Support was also provided by the Graduate School and the Office of the Vice Chancellor for Research and Graduate Education at the University of Wisconsin-Madison with funding from the Wisconsin Alumni Research Foundation.

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  1. Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, 53706, USA

    Zachary T. Morrow, Zachary M. Powers & John-Demian Sauer

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Morrow, Z.T., Powers, Z.M. & Sauer, JD. Listeria monocytogenes Cancer Vaccines: Bridging Innate and Adaptive Immunity. Curr Clin Micro Rpt 6, 213–224 (2019). https://doi.org/10.1007/s40588-019-00133-4

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