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Current Clinical Microbiology Reports

, Volume 6, Issue 1, pp 34–43 | Cite as

Pathways to Understanding Virus-Host Metabolism Interactions

  • John G. PurdyEmail author
Virology (A Nicola, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Virology

Abstract

Purpose of Review

Viruses have vast diversity in terms of virion structure, genomic content, and host. All viruses, however, rely on host metabolism as none encode a metabolic network. Although virus-host metabolism interactions are critical to infection, little is understood regarding viral remodeling of its host metabolic network. Likewise, for most viruses, we have yet to identify if and how viruses govern the activity of metabolic pathways. Fortunately, metabolic analyses are becoming more accessible to virologist, thanks in large part to advances in mass spectrometry-based approaches. A brief overview of virus-metabolism interactions and the current state-of-the-art approaches to metabolomics, lipidomics and metabolic analyses are discussed.

Recent Findings

In the last several years, multiple metabolomic and lipidomic studies during virus infection have been reported. Products of the metabolic network support or limit infection. When considering how viruses interact with host metabolism it is critical for virologist to think beyond their copy of a Biochemistry textbook, as computational and analytical advances in recent years have led to novel discoveries in metabolism. Some of those advances and discoveries are introduced here, with a focus on the recent findings in virus-host metabolism interactions.

Summary

Metabolism is important to viral infections beyond simply keeping a cell alive while the virus replicates. Recent advances in tools and methods to dissect metabolism during infection have led to novel findings in infection-induced changes in metabolism. Continued research is necessary to build comprehensive understanding of how viruses interact with their host’s metabolic network.

Keywords

Viral remodeling Metabolism Metabolomics Lipidomics Mass spectrometry 

Notes

Compliance With Ethical Standards

Conflict of Interest

The author declares that he has no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Immunobiology and BIO5 InstituteUniversity of ArizonaTucsonUSA

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