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Brucella abortus: Current Research and Future Trends

  • Bacteriology (N Borel, Section Editor)
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Abstract

Purpose of review

Brucella abortus is a Gram-negative, facultative intracellular bacterium of the genus Brucella and is the main causative agent of bovine brucellosis. An update on the recent research on B. abortus and diseases caused by B. abortus in animals and humans is provided.

Recent findings

In the last decade, intense efforts have focused on understanding the pathobiology, taxonomy, proteomics, and genomics of B. abortus. Proteomic analyses and complete genomic sequencing have provided information on the virulence of the brucellae; this information will help to identify novel antigens for better serodiagnosis and promising candidates for subunit vaccines.

Summary

The bacteria affect a broad variety of animal host species as well as humans, causing seriously debilitating disease. Short-course treatment regimens or licensed vaccines in humans do not exist. Diagnosis remains a challenge in endemic and non-endemic countries, and the effectiveness of current surveillance and control programs in animals is still under discussion. Brucellosis in bovines is a re-emerging disease in developing countries but is neglected by public (veterinary) health and family doctors.

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Authors and Affiliations

  1. OIE Reference Laboratory for Brucellosis, Friedrich-Loeffler-Institut, Federal Federal Research Institute for Animal Health, Institute of Bacterial Infections and Zoonoses, Naumburger Str. 96a, 07743, Jena, Germany

    Tariq Jamil, Falk Melzer, John Njeru, Hosny El-Adawy, Heinrich Neubauer & Gamal Wareth

  2. Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, 13736, Egypt

    Gamal Wareth

  3. Centre for Microbiology Research, Kenya Medical Research Institute, P. O. Box, 19464-00202, Nairobi, Kenya

    John Njeru

  4. Faculty of Veterinary Medicine, Kafr Elsheikh University, Kafr El-Sheikh, 35516, Egypt

    Hosny El-Adawy

Authors
  1. Tariq Jamil
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  2. Falk Melzer
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  3. John Njeru
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  4. Hosny El-Adawy
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  5. Heinrich Neubauer
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  6. Gamal Wareth
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Correspondence to Gamal Wareth.

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Jamil, T., Melzer, F., Njeru, J. et al. Brucella abortus: Current Research and Future Trends. Curr Clin Micro Rpt 4, 1–10 (2017). https://doi.org/10.1007/s40588-017-0052-z

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