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Role of Predictive Mortality Calculator in Antenatal Assessment of Congenital Diaphragmatic Hernia

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Journal of Fetal Medicine


Congenital diaphragmatic hernia (CDH) is one of the most common major congenital anomalies. In utero visceral organ herniation into the thoracic cavity can result in lung hypoplasia and pulmonary hypertension may ensue. Post-natal mortality rates in isolated CDH remain high reaching up to 80% in severe cases. Several prenatal predictors of morbidity and mortality have been proposed. Reliable predictive markers can aid clinicians in providing effective family counselling, prediction of survival, and propose therapeutic options. Decreased total fetal lung volume (TFLV) via magnetic resonance imaging (MRI) has been reported to be significantly associated with mortality. We report on 2 cases of CDH, with fetal MRI performed at third trimester, focusing on the TFLV and observed-to-expected TFLV. We would like to highlight the importance of predictive mortality calculator which provides statistical data for healthcare providers in counselling families and aids in risk-stratification.

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All authors have accepted responsibility for the entire content of this manuscript and approved its submission. All authors contributed to the study conception and design. Material preparation and analysis were performed by Azril Ishak and Hasyma Abu Hassan. The first draft of the manuscript was written by Azril Ishak and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Hasyma Abu Hassan.

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The local Institutional Review Board deemed the study exempt from review.

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Informed consent was obtained from all individuals included in this study. The subjects have given their written informed consent to publish their cases and can be made available upon request.

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Ishak, A., Abu Hassan, H., Mohd Jamil, A.A. et al. Role of Predictive Mortality Calculator in Antenatal Assessment of Congenital Diaphragmatic Hernia. J. Fetal Med. 8, 211–215 (2021).

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