Early Second-Trimester Spontaneous Miscarriage Due to Fourth Ventricle Choroid Plexus Papilloma

  • George S. Stoyanov
  • Ina Kobakova
  • Dimo Stoyanov
  • Marin Zhelezov
  • Meglena Angelova
  • Deyan Dzhenkov
  • Reneta Georgieva
  • Lora Ayetola
  • Emil Kovachev
  • Peter Ghenev
  • Anton B. Tonchev
Original Article
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Abstract

Miscarriage due to fetal tumors is an extremely rare finding, with a varying incidence from 1.7 to 13.5 per 100,000 live births, with central nervous system tumors occupying a minority of these cases. Herein, we report the gross morphological and histological findings of a 17-gestational week spontaneous miscarriage in a 27 year old multi-gravida due to a fourth ventricle choroid plexus papilloma (CPP). The CPP was composed of a pronoun fibro-vascular stroma covered with a dense lining of tall cuboid sparsely ciliated single cell layer with rich in chromatin nuclei. The cytoplasm of the CPP covering cells was intensely colored when compared to the pale cytoplasm of the covering cells of the choroid plexus collected from the lateral ventricle, which also lacked in such pronoun fibrovascular stroma. The fourth ventricle was significantly dilated with parenchymal compression of nervous tissue towards the chondral fetal cranium.

Keywords

Spontaneous miscarriage Fetal tumor Choroid plexus papilloma Turner syndrome 

Notes

Acknowledgements

The authors would like to thank Elena Boeva and Pepa Stankova for their careful slide preparation of the fragile specimens collected.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from all participants.

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Copyright information

© Society of Fetal Medicine 2018

Authors and Affiliations

  • George S. Stoyanov
    • 1
    • 2
    • 3
  • Ina Kobakova
    • 1
  • Dimo Stoyanov
    • 2
  • Marin Zhelezov
    • 2
  • Meglena Angelova
    • 2
  • Deyan Dzhenkov
    • 1
  • Reneta Georgieva
    • 4
  • Lora Ayetola
    • 4
  • Emil Kovachev
    • 5
  • Peter Ghenev
    • 1
  • Anton B. Tonchev
    • 2
  1. 1.Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of MedicineMedical University – Varna “Prof. Dr. Paraskev Stoyanov”VarnaBulgaria
  2. 2.Department of Anatomy and Cell Biology, Faculty of MedicineMedical University – Varna “Prof. Dr. Paraskev Stoyanov”VarnaBulgaria
  3. 3.Department of Physiology and Pathophysiology, Faculty of MedicineMedical University – Varna “Prof. Dr. Paraskev Stoyanov”VarnaBulgaria
  4. 4.Faculty of MedicineMedical University – Varna “Prof. Dr. Paraskev Stoyanov”VarnaBulgaria
  5. 5.Department of Obstetrics and Gynecology, Faculty of MedicineMedical University – Varna “Prof. Dr. Paraskev Stoyanov”VarnaBulgaria

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