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Cordocentesis

  • Review Article
  • Published:
Journal of Fetal Medicine

Abstract

Cordocentesis is an ultrasound-guided procedure to obtain fetal band from umbilical cord. It is indicated for rapid evaluation of fetal karyotype, fetal hematological disorders, and identification of fetal infection. Results are available in 48–72 h. If patient presents late and the results from amniocentesis would not be available within time for elective termination of pregnancy, it is the preferred procedure. Therapeutic indications include intravascular cord transfusion in Rh isoimmunization, fetal anemia, or drug administration. Procedure is performed from 18 weeks of gestation onward. Umbilical cord at placental attachment is the site of choice for puncture. We use 21–22 gauge spinal needle for this procedure. It needs expertise and is safe if performed by experienced surgeon. Single dose of antibiotic prior to procedure can be given. The rate of pregnancy loss varies and depends on the indication of procedure. Overall procedure related loss is <2 %.

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References

  1. Hobbins JC, Mahoney MJ. In utero diagnosis of hemoglobinopathies—technic for obtaining fetal blood. N Engl J Med. 1974;290:1065–7.

    Article  CAS  PubMed  Google Scholar 

  2. Daffos F, Cappella-Pavlovsky M, Forestier F. Fetal blood sampling via the umbilical cord using a needle guided by ultrasound. Report of 66 cases. Prenat Diagn. 1983;3:271–7.

    Article  CAS  PubMed  Google Scholar 

  3. Paniggrahi I, Ahmed RP, Kannan M, Kabra M, Deka D, Sexena R. Cord blood analysis for prenatal diagnosis of thalassemia major and hemophilia A. Indian Pediatr. 2005;42(6):577–81.

    Google Scholar 

  4. Loukogeorgakis SP, Flake AW. In utero stem cell and gene therapy: current status and future perspectives. Eur J Pediatr Surg. 2014;24(3):237–45.

    Article  PubMed  Google Scholar 

  5. Kabra M, Saxena R, Chinnappan D, Sanders V, Deka D, Buckshee K, et al. Karyotyping of at risk fetuses by cordocentesis in advanced gestation. Indian J Med Res. 1996;104:288–91.

    CAS  PubMed  Google Scholar 

  6. Mathur R, Dubey S, Hamilton S, Singh G, Deka D, Kriplani A, et al. Rapid prenatal karyotyping using foetal blood obtained by cordocentesis. Natl Med J India. 2002;15(2):75–7.

    PubMed  Google Scholar 

  7. Ranjan R, Biswas A, Kannan M, Meena A, Deka D, Saxena R. Prenatal diagnosis of haemophilia A by chorionic villus sampling and cordocentesis: all India Institute of Medical Science experience. Vox Sang. 2007;92(1):79–84.

    Article  CAS  PubMed  Google Scholar 

  8. Mota L, Ghosh K, Shetty S. Second trimester antenatal diagnosis in rare coagulation factor deficiencies. J Pediatr Hematol Oncol. 2007;29(3):137–9.

    Article  PubMed  Google Scholar 

  9. Shetty S, Ghosh K, Mohanty D. Prenatal diagnosis in a haemophilia A family by both factor VIII activity and antigen measurements. J Assoc Physicians India. 2003;51:916–8.

    PubMed  Google Scholar 

  10. Deka D, Malhotra N, Takkar D, Mittal S, Kriplani A, Roy KK. Prenatal diagnosis and assessment of fetal malformations by ultrasonography in India. Indian J Pediatr. 1999;66(5):737–49.

    Article  CAS  PubMed  Google Scholar 

  11. Mishra A, Gupta M, Dalvi A, Ghosh K, Madkaikar M. Rapid flow cytometric prenatal diagnosis of primary immunodeficiency (PID) disorders. J Clin Immunol. 2014;34(3):316–22.

    Article  CAS  PubMed  Google Scholar 

  12. Tongsong T, Wanapirak C, Kunaylkatikul C, Sirirchotlyakul S, Plyamongkol W, Chanprapaph P. Cordocentesis at 16–24 weeks of gestation: experience of 1,320 cases. Prenat Diagn. 2000;20(3):224–8.

    Article  CAS  PubMed  Google Scholar 

  13. Tongsong T, Khumpho R, Wanapirak C, Plyamongkol W, Sirichotlyakul S. Effect of umbitical cord bleeding following mid-pregnancy cordocentesis on pregnancy outcomes. Gynecol Obstet Invest. 2012;74(4):298–303.

    Article  PubMed  Google Scholar 

  14. Tongsong T, Wanapirak C, Plyamongkol W, Sirichotiyakul S, Tongprasert F, Srisupundit K, et al. Second trimester cordocentesis and the risk of small for gestational age and preterm birth. Obstet Gynaecol. 2014;124(5):919–25.

    Article  Google Scholar 

  15. Liao C, Wei J, Li Q, Li L, Li J, Li D. Efficacy and safety of cordocentesis for prenatal diagnosis. Int J Gynaecol Obstet. 2006;93(1):13–7.

    Article  PubMed  Google Scholar 

  16. Kohatsu M, Carvalho MH, Vieira RP, Francisco RP, Filho AG, Zugaib M. Analysis of fetal and Maternal results from fetal genetic in various procedure: an exploratory study at a university hospital. Rev Assoc Med Bras. 2012;58(6):703–8.

    Article  PubMed  Google Scholar 

  17. Wilson RD, Gagnon A, Audibret F, Campagnolo C, Carroll J, Committee Genetics, et al. Prenatal diagnostic procedures and techniques to obtain a diagnostic fetal specimen or tissues: maternal and fetal risk and benefit. J Obstet Gynaecol Can. 2015;37(7):656–70.

    Article  PubMed  Google Scholar 

  18. Jesus I, Simon E, Potin J, Arliat C, Perrotin F. Preductive factor for fetal tolerance to cordocentesis a monocentric retrospective study. Gynaecol Obstet Fertil. 2012;40(12):734–40.

    Article  Google Scholar 

  19. Kim SR, Wen HS, Lee PR, Kim A. Four dimension ultrasound guidance of prenatal invasive procedure. Ultrasound Obstet Gynecol. 2005;26(6):645–63.

    CAS  Google Scholar 

  20. Tongprasert F, Tongsong T, Wanapirak C, Sirichotiyakul S, Pujamongkol W. Cordocentesis in multifetal pregnancies. Prenat Diagn. 2007;27:1100.

    Article  PubMed  Google Scholar 

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Correspondence to Nutan Agarwal.

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Agarwal, N. Cordocentesis. J. Fetal Med. 3, 71–75 (2016). https://doi.org/10.1007/s40556-016-0083-1

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  • DOI: https://doi.org/10.1007/s40556-016-0083-1

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