Current Treatment Options in Allergy

, Volume 5, Issue 1, pp 133–139 | Cite as

How Can We Influence the Performance of Drug Challenge in Future Treatment

  • Aslı Gelincik
  • Gülfem E. Celik
Drug Allergy (MJ Torres Jaén, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Drug Allergy


Drug provocation tests are assumed to be the gold standard of drug allergy workup by ensuring the most objective results in clinical observation irrespective of the underlying mechanism of the reaction. Despite its some disadvantages, it is still one of the cornerstones of the drug allergy diagnosis. In this review, new methods for improving diagnostic accuracy of drug provocation tests will be discussed. In this sense, extended challenges are recently shown to have better outcome especially in diagnosing non-immediate reactions due to antibiotics. In children with non-immediate mild cutaneous reactions, provocation tests are becoming to take place of skin tests with promising results. Furthermore, drug provocation tests have been shown to prevent unnecessary desensitization protocols in newly developed drugs such as biological agents. These new data on diagnostic performance of drug provocation test seem to influence the future treatments in patients with drug hypersensitivity reactions.


Drug provocation tests Extended provocation Drug allergy Non-immediate reactions Beta-lactams 


Compliance With Ethical Standards

Conflict of Interest

Aslı Gelincik declares that she has no conflict of interest.

Gülfem E. Celik declares that she has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as• Of importance •• Of major importance

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Internal Medicine, Division of Immunology and AllergyIstanbul University School of MedicineIstanbulTurkey
  2. 2.Department of Chest Diseases, Division of Immunology and AllergyAnkara University School of MedicineAnkaraTurkey

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