Mast Cell Activation Syndromes and Environmental Exposures
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Mast cell activation syndromes (MCAS) are an emerging entity that includes a heterogeneous group of diseases presenting with typical signs and symptoms secondary to the release of mast cell (MC) mediators. Triggering factors underlying the activation of mast cells show a wide variability, and episodes of MC-mediator release are usually triggered by idiopathic or by mixed causes, which makes avoidance recommendations difficult to devise. Sometimes, environmental or occupational exposures are responsible for MC activation. In this article, we review the main workplace environment eliciting factors described in MCAS and the current guidance on treatment.
KeywordsClonal Environmental Mast cell Mast cell activation syndrome Mastocytosis Occupational
We thank Isabel Coman for her technical assistance with the revision of the English version of the manuscript.
This work was supported by a grant from the Sociedad Española Alergia e Inmunología Clínica 2014.
Compliance with ethical standards
Conflict of interest
David González-de-Olano declares that he has no conflict of interest. Javier Domínguez-Ortega declares that he has no conflict of interest. Silvia Sánchez-García declares that she has no conflict of interest.
Human and animal rights and informed consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
References and Recommended Reading
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