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Cardiac variables associated with atrial fibrillation occurrence and mortality in octogenarians implanted with dual chamber permanent pacemakers

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Abstract

Background

There is a dearth of data on the predictors of atrial fibrillation (AF) and the association between AF and long-term mortality in octogenarians with dual-chamber permanent pacemakers (PPM). We investigate the occurrence of AF and whether it is associated with overall mortality among octogenarians with dual-chamber PPM implants.

Methods

Three hundred and fifty-four patients with PPM implants were divided into two groups based on their long-term survival status. Baseline characteristics, laboratory variables, and echocardiographic variables were then compared between the groups, and independent predictors of the long-term incidence of AF and mortality were determined.

Results

Multivariable Cox regression analysis performed after adjusting for the parameters in univariable analysis revealed that diabetes, urea levels, albumin levels, paced QRS duration, and the frequency of atrial high-rate episodes (AHREs) were independently associated with a long-term risk of AF in octogenarians after having dual chamber PPMs implanted. The left ventricular (LV) ejection fraction, left atrial (LA) anteroposterior diameter, and AHRE + AF (HR 1.498, 95%CI 1.003–2.237, p = 0.048) were independent risk factors for the long-term mortality in octogenarians receiving dual-chamber PPMs implants.

Conclusion

The occurrence of AF following dual-chamber PPM implantation is a significant prognostic factor in octogenarian patients.

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Authors and Affiliations

  1. Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Tibbiye street, 34668, Istanbul, Turkey

    Mert İlker Hayıroğlu, Göksel Çinier, Gizem Yüksel, Levent Pay, Kıvanç Keskin, Cahit Coşkun, Gökçem Ayan & Ahmet İlker Tekkeşin

  2. Department of Cardiology, Haydarpasa Sultan II. Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

    Tufan Çınar & Vedat Çiçek

Authors
  1. Mert İlker Hayıroğlu
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  2. Tufan Çınar
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  3. Göksel Çinier
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  4. Gizem Yüksel
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  5. Levent Pay
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  6. Kıvanç Keskin
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  9. Vedat Çiçek
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  10. Ahmet İlker Tekkeşin
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Correspondence to Mert İlker Hayıroğlu.

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The study design was approved by the Health Sciences University Ethics Committee.

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Hayıroğlu, M.İ., Çınar, T., Çinier, G. et al. Cardiac variables associated with atrial fibrillation occurrence and mortality in octogenarians implanted with dual chamber permanent pacemakers. Aging Clin Exp Res 34, 2533–2539 (2022). https://doi.org/10.1007/s40520-022-02194-w

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  • DOI: https://doi.org/10.1007/s40520-022-02194-w

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