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Association between organ damage and visceral adiposity index in community-dwelling elderly Chinese population: the Northern Shanghai Study

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Abstract

Background

The visceral adiposity index (VAI) is a newly developing indicator about visceral fat function and insulin resistance. This research aims to assess the association between organ damage and VAI in the community-dwelling elderly Chinese population.

Methods

In total, 3363 elderly participants were recruited between June 2014 and August 2019. VAI was used to measure visceral adipose accumulation, and organ damage was measured with standardized methods, including arterial stiffness, lower extremity atherosclerosis, carotid hypertrophy, left ventricular hypertrophy, micro-albuminuria, and chronic kidney disease.

Results

According to multivariable linear regression analysis, VAI was related to carotid-femoral pulse wave velocity (cf-PWV; β = 0.047, P = 0.024), urine albumin to creatinine ratio (UACR; β = 3.893, P = 0.008), estimated glomerular filtration rate (eGFR; β =  − 0.526, P = 0.003) and loge(ankle-to-brachial index) (ABI; β = -0.003, P = 0.024). Using multivariable stepwise logistic regression model, higher VAI was found to be significantly related to cf-PWV > 10 m/s (OR 1.44, [95% CI 1.17–1.78]; Pfor trend < 0.001), and chronic kidney disease (CKD; OR 1.54, [95% CI 1.09–2.20]; Pfor trend = 0.015).

Conclusions

Since higher VAI is related to increased risk of arterial stiffness and CKD, it may serve as a useful index for the assessment of arteriosclerosis and CKD in elderly population.

Trial registration

NSS, NCT02368938.

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Data availability

The datasets generated and analyzed during the current study are not publicly available because this study is still on-going, but are available from the corresponding author on reasonable request.

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Funding

This study was supported by the Shanghai Municipal Government (15GWZK1002), the National Key Technology R&D Program during the Thirteenth Five-Year Plan Period (China) (2017YFC0111800), National Nature Science Foundation of China (81670377) and the Shanghai Excellent Young Scholars Program (2017YQ065).

Author information

Author notes

  1. Chong Xu and Song Zhao should be considered joint first author.

Authors and Affiliations

  1. Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China

    Chong Xu, Song Zhao, Shikai Yu, Chen Chi, Ximin Fan, Hongwei Ji, Rusitanmujiang Maimaitiaili, Jiadela Teliewubai, Yi Zhang & Yawei Xu

  2. Department of Emergency, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China

    Xiaofeng Li

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  1. Chong Xu
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Contributions

YX and YZ designed the protocol and revised the manuscript. CX and SZ carried out the statistical analysis and wrote the manuscript. SY, CC, XF, HJ, RM, JT assisted with data collection. XL contributed to the discussion. All authors read and approved the final version of this manuscript.

Corresponding authors

Correspondence to Yi Zhang or Yawei Xu.

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Competing interests

The authors declare that they have no competing interests.

Ethics approval

The Ethics Committee of Shanghai Tenth People’s Hospital has approved the present study. The study was registered in ClinicalTrials. gov (Identifier: NCT02368938 and date of registration: February 15, 2015).

Statement of human rights

This study was performed in line with the principles of the Declaration of Helsinki.

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Xu, C., Zhao, S., Yu, S. et al. Association between organ damage and visceral adiposity index in community-dwelling elderly Chinese population: the Northern Shanghai Study. Aging Clin Exp Res 33, 2291–2297 (2021). https://doi.org/10.1007/s40520-020-01752-4

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