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Sulfonylureas use and fractures risk in elderly patients with type 2 diabetes mellitus: a meta-analysis study

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Abstract

Background and aims

Sulfonylureas are widely used in patients with type 2 diabetes; meanwhile, the increasing fractures risks especially in the old are gradually taken into consideration. This meta-analysis aimed at investigating whether sulfonylureas could influence the risk of fractures in type 2 diabetes (T2DM) in the elder patients (≥ 65 years old).

Methods

We searched the PubMed and other databases to screen eligible studies. Two authors independently extracted data according to the selection criteria for each study. The Newcastle–Ottawa scale was used to evaluate the quality. Subgroups and sensitivity analyses were performed and publication bias was assessed.

Result

A total of 7 studies involving 464,121 individuals were included in our meta-analysis. The pooled risk ratio for developing fracture in sulfonylurea users with type 2 diabetes (≥ 65 years old) was 1.26 (95% CI 1.15–1.39). Sensitivity analyses confirmed the stability of the results and there was no publication bias.

Conclusions

Sulfonylureas could add the risk of fractures among the old with type 2 diabetes. Initial sulfonylureas therapy in both men and women should be done prudently.

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Funding

This research was done without receiving any funding from other institutions.

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Authors and Affiliations

  1. Department of Cardiology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China

    Yujia Tao

  2. Yangzhou Center for Disease Control and Prevention, Yang Zhou, China

    Meng E

  3. Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China

    Jingjing Shi

  4. Department of Endocrinology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China

    Zhen Zhang

Authors
  1. Yujia Tao
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  2. Meng E
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  3. Jingjing Shi
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  4. Zhen Zhang
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Correspondence to Zhen Zhang.

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Tao, Y., E, M., Shi, J. et al. Sulfonylureas use and fractures risk in elderly patients with type 2 diabetes mellitus: a meta-analysis study. Aging Clin Exp Res 33, 2133–2139 (2021). https://doi.org/10.1007/s40520-020-01736-4

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  • DOI: https://doi.org/10.1007/s40520-020-01736-4

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