Sulfonylureas use and fractures risk in elderly patients with type 2 diabetes mellitus: a meta-analysis study


Background and aims

Sulfonylureas are widely used in patients with type 2 diabetes; meanwhile, the increasing fractures risks especially in the old are gradually taken into consideration. This meta-analysis aimed at investigating whether sulfonylureas could influence the risk of fractures in type 2 diabetes (T2DM) in the elder patients (≥ 65 years old).


We searched the PubMed and other databases to screen eligible studies. Two authors independently extracted data according to the selection criteria for each study. The Newcastle–Ottawa scale was used to evaluate the quality. Subgroups and sensitivity analyses were performed and publication bias was assessed.


A total of 7 studies involving 464,121 individuals were included in our meta-analysis. The pooled risk ratio for developing fracture in sulfonylurea users with type 2 diabetes (≥ 65 years old) was 1.26 (95% CI 1.15–1.39). Sensitivity analyses confirmed the stability of the results and there was no publication bias.


Sulfonylureas could add the risk of fractures among the old with type 2 diabetes. Initial sulfonylureas therapy in both men and women should be done prudently.

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Correspondence to Zhen Zhang.

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Tao, Y., E, M., Shi, J. et al. Sulfonylureas use and fractures risk in elderly patients with type 2 diabetes mellitus: a meta-analysis study. Aging Clin Exp Res (2020).

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  • Sulfonylureas
  • Type 2 diabetes
  • Fracture risk
  • Elder people
  • Meta-analysis