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Pro-inflammatory status is not a limit for longevity: case report of a Sicilian centenarian

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References

  1. Caruso C (ed) (2019) Centenarians. An example of positive biology. Springer, Cham. https://doi.org/10.1007/978-3-030-20762-5

    Book  Google Scholar 

  2. Accardi G, Aprile S, Candore G et al (2019) Genotypic and phenotypic aspects of longevity: results from a sicilian survey and implication for the prevention and treatment of age-related diseases. Curr Pharm Des 25:228–235. https://doi.org/10.2174/1381612825666190313115233

    Article  CAS  PubMed  Google Scholar 

  3. Accardi G, Aiello A, Aprile S et al (2020) The phenotypic characterization of the cammalleri sisters, an example of exceptional longevity. Rejuvenation Res. https://doi.org/10.1089/rej.2019.2299

    Article  PubMed  Google Scholar 

  4. Cammarata G, Duro G, Di Chiara T et al (2019) Circulating miRNAs in successful and unsuccessful aging. A mini-review. Curr Pharm Des 25:4150–4153. https://doi.org/10.2174/1381612825666191119091644

    Article  CAS  PubMed  Google Scholar 

  5. Noren Hooten N, Fitzpatrick M, Wood WH 3rd et al (2013) Age-related changes in microRNA levels in serum. Aging (Albany NY) 5:725–740

    Article  Google Scholar 

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Acknowledgements

The original work was supported by 20157ATSLF project (Discovery of molecular, and genetic/epigenetic signatures underlying resistance to age-related diseases and comorbidities), granted by the Italian Ministry of Education, University and Research to C.C. and G.C.

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Author notes

  1. Anna Aiello and Giulia Accardi contributed equally.

Authors and Affiliations

  1. Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Corso Tuköry, 211, 90134, Palermo, Italy

    Anna Aiello, Giulia Accardi, Stefano Aprile, Calogero Caruso, Mattia Emanuela Ligotti & Giuseppina Candore

  2. Department of Laboratory Medicine, “P. Giaccone” University Hospital, Palermo, Italy

    Rosalia Caldarella & Marcello Ciaccio

  3. Institute for Biomedical Research and Innovation, National Research Council of Italy, Palermo, Italy

    Giuseppe Cammarata

  4. Department of Biomedical Sciences, University of Sassari, Sassari, Italy

    Ciriaco Carru

  5. Unit of Clinical Biochemistry, Clinical Molecular Medicine, and Laboratory Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy

    Marcello Ciaccio & Caterina Maria Gambino

  6. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA

    Immaculata De Vivo

  7. Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy

    Sonya Vasto

Authors
  1. Anna Aiello
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  2. Giulia Accardi
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  3. Stefano Aprile
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  4. Rosalia Caldarella
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  5. Giuseppe Cammarata
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  6. Ciriaco Carru
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  7. Calogero Caruso
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  8. Marcello Ciaccio
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  9. Immaculata De Vivo
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  10. Caterina Maria Gambino
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  11. Mattia Emanuela Ligotti
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  12. Sonya Vasto
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  13. Giuseppina Candore
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Corresponding author

Correspondence to Calogero Caruso.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The Institutional Ethics Committee (“Paolo Giaccone”, University Hospital) approved the DESIGN study protocol (Nutrition and Longevity, No. 032017). The study was conducted in accordance with the Declaration of Helsinki and its amendments.

Statement of human and animal rights

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from the centenarian assisted by her daughter.

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Electronic supplementary material

Below is the link to the electronic supplementary material where oxidative and inflammatory markers of CC are compared with that of the different age groups of female population studied in the DESIGN project.

Supplementary file1 (DOCX 22 kb)

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Aiello, A., Accardi, G., Aprile, S. et al. Pro-inflammatory status is not a limit for longevity: case report of a Sicilian centenarian. Aging Clin Exp Res 33, 1403–1407 (2021). https://doi.org/10.1007/s40520-020-01628-7

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  • DOI: https://doi.org/10.1007/s40520-020-01628-7

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