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The prognostic role of age in primary cutaneous B-cell lymphoma: a proposal derived from a population-based registry

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Abstract

Purpose

A few prognostic predicting systems existed for primary cutaneous B-cell lymphoma (PCBCL). However, none of them took age into consideration. We sought to declare the prognostic role of age in PCBCL.

Materials and methods

A total of 4859 patients were identified in the surveillance, epidemiology and end results data, spanning 1975–2016. The association between age and survival was determined using unadjusted and adjusted proportional hazard analysis.

Results

There was a uni-modal distribution of age, with most in the seventh decade (22%), followed by the sixth and eighth decades (19%). As a continuous variable, age was demonstrated to have an adverse effect on overall survival (OS, HR, 1.077, 95% CI 1.073–1.082, p = 0.000) and cancer-specific survival (CSS, HR, 1.099, 95% CI 1.092–1.106, p = 0.000) after adjusted proportional hazard analysis. Patients aged ≤ 60 years had significantly higher survival rates than those aged > 60 (5-year OS was 93% vs 64%, 10-year OS was 90% vs 45%, p = 0.000; 5-year CSS was 98% vs 80%, 10-year CSS 96% was 62%, p = 0.000). Similar survival trends were also observed in different sub-group analyses, including disease with different stages (p = 0.000), different histology subgroups (p = 0.000), and different sites (p = 0.000).

Conclusion

Age has an important effect on overall survival and cancer-specific survival. The addition of age to the primary site, histology, and stage improves predicting long-term outcomes in cutaneous B-cell lymphoma.

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References

  1. Bradford PT, Devesa SS, Anderson WF et al (2009) Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases. Blood 113:5064–5073

    Article  CAS  Google Scholar 

  2. Willemze R, Kerl H, Sterry W et al (1997) EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer. Blood 90:354–371

    CAS  PubMed  Google Scholar 

  3. Smith BD, Smith GL, Cooper DL et al (2005) The cutaneous B-cell lymphoma prognostic index: a novel prognostic index derived from a population-based registry. J Clin Oncol 23:3390–3395

    Article  Google Scholar 

  4. Smith BD, Glusac EJ, McNiff JM et al (2004) Primary cutaneous B-cell lymphoma treated with radiotherapy: a comparison of the European Organization for Research and Treatment of Cancer and the WHO classification systems. J Clin Oncol 22:634–639

    Article  Google Scholar 

  5. Sander CA, Flaig MJ, Jaffe ES (2001) Cutaneous manifestations of lymphoma: a clinical guide based on the WHO classification. World Health Organization. Clin Lymphoma 2:86–100 (discussion 101-2)

    Article  CAS  Google Scholar 

  6. Hsi ED (2017) 2016 WHO Classification update—what's new in lymphoid neoplasms. Int J Lab Hematol 39:14–22

    Article  Google Scholar 

  7. Willemze R, Jaffe ES, Burg G et al (2005) WHO-EORTC classification for cutaneous lymphomas. Blood 105:3768–3785

    Article  CAS  Google Scholar 

  8. Willemze R, Hodak E, Zinzani PL et al (2018) Primary cutaneous lymphomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 29:30–40

    Article  Google Scholar 

  9. Mian M, Marcheselli L, Luminari S et al (2011) CLIPI: a new prognostic index for indolent cutaneous B cell lymphoma proposed by the International Extranodal Lymphoma Study Group (IELSG 11). Ann Hematol 90:401–408

    Article  Google Scholar 

  10. Zinzani PL, Quaglino P, Pimpinelli N et al (2006) Prognostic factors in primary cutaneous B-cell lymphoma: the Italian Study Group for Cutaneous Lymphomas. J Clin Oncol 24:1376–1382

    Article  Google Scholar 

  11. Hamilton SN, Wai ES, Tan K et al (2013) Treatment and outcomes in patients with primary cutaneous B-cell lymphoma: the BC cancer agency experience. Int J Radiat Oncol Biol Phys 87:719–725

    Article  Google Scholar 

  12. Haverkos B, Tyler K, Gru AA et al (2015) Primary cutaneous B-Cell lymphoma: management and patterns of recurrence at the multimodality cutaneous lymphoma clinic of The Ohio State University. Oncologist 20:1161–1166

    Article  CAS  Google Scholar 

  13. Lee WJ, Lee SH, Moon IJ et al (2016) Relative frequency, clinical features, and survival outcomes of 395 patients with cutaneous lymphoma in korea: a subgroup analysis per 10-year period. Acta Derm Venereol 96:888–893

    Article  Google Scholar 

  14. Grange F, Bekkenk MW, Wechsler J et al (2001) Prognostic factors in primary cutaneous large B-cell lymphomas: a European multicenter study. J Clin Oncol 19:3602–3610

    Article  CAS  Google Scholar 

  15. Senff NJ, Hoefnagel JJ, Jansen PM et al (2007) Reclassification of 300 primary cutaneous B-cell lymphomas according to the new WHO-EORTC classification for cutaneous lymphomas: comparison with previous classifications and identification of prognostic markers. J Clin Oncol 25:1581–1587

    Article  Google Scholar 

  16. De Felice F, Grapulin L, Pieroni A et al (2018) Radiation therapy in indolent primary cutaneous B cell lymphoma: a single institute experience. Ann Hematol 97:2411–2416

    Article  Google Scholar 

  17. Sumida H, Sugaya M, Miyagaki T et al (2013) Frequent relapse and irradiation strategy in primary cutaneous diffuse large B-cell lymphoma, leg-type. Acta Derm Venereol 93:97–98

    Article  Google Scholar 

  18. Liu WP, Song YQ, Zheng W et al (2013) Aggressive behavior and elevated lactate dehydrogenase at baseline confer inferior prognosis in patients with primary cutaneous lymphoma. Clin Lymphoma Myeloma Leuk 13:534–540

    Article  CAS  Google Scholar 

  19. Kim YH, Willemze R, Pimpinelli N et al (2007) TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (EORTC). Blood 110:479–484

    Article  CAS  Google Scholar 

  20. Grange F, Petrella T, Beylot-Barry M et al (2004) Bcl-2 protein expression is the strongest independent prognostic factor of survival in primary cutaneous large B-cell lymphomas. Blood 103:3662–3668

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, The Second Hospital of Shanxi Medical University, NO. 382, Wuyi Road, Shanxi, 030001, China

    Xiaoqiang Jia, Yu Ma & Wen Cen

  2. Department of Oncology, The Second Hospital of Shanxi Medical University, Shanxi, 030001, China

    Gang Jin

  3. Department of Pathology, The Second Hospital of Shanxi Medical University, Shanxi, 030001, China

    Xiaodong Wen

  4. Department of Pharmacy, The Second Hospital of Shanxi Medical University, Shanxi, 030001, China

    Wenjun Zhang

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  1. Xiaoqiang Jia
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  2. Gang Jin
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  3. Yu Ma
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  4. Wen Cen
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  5. Xiaodong Wen
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Correspondence to Xiaoqiang Jia or Gang Jin.

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The data accessed froma database are freely available and deidentfied; therefore, this study did not require a research ehics board/institution review board approval.

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Jia, X., Jin, G., Ma, Y. et al. The prognostic role of age in primary cutaneous B-cell lymphoma: a proposal derived from a population-based registry. Aging Clin Exp Res 33, 429–436 (2021). https://doi.org/10.1007/s40520-020-01544-w

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  • DOI: https://doi.org/10.1007/s40520-020-01544-w

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