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Frailty index is associated with increased risk of elevated BNP in an elderly population: the Rugao Longevity and Ageing Study

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Abstract

Background and aims

To explore whether frailty, defined by frailty index (FI), is associated with the risk of elevated B-type natriuretic peptide (BNP), a surrogate endpoint of cardiovascular events.

Methods

Data of 1382 community-dwelling elders who had no documented cardiovascular diseases aged 70–84 years from the ageing arm of the Rugao Longevity and Ageing Study was used. Traditional risk factor index (TI) was constructed using eight established cardiovascular-related risk factors. FI was constructed using 36 health deficits. Elevated BNP was defined as BNP ≥ 100pg/mL. Cardiovascular events include incident major cardiovascular events and cardiovascular death.

Results

During a 3-year follow-up period, 97 participants had cardiovascular events. TI was not associated with the risk of elevated BNP, but was associated with cardiovascular events (HR = 1.16, 95% CI 1.01–1.34). Frailty index was not only associated with cardiovascular events (HR = 1.32, 95% CI 1.06–1.64), but also associated with elevated BNP with an OR of 1.22 (95% CI 1.02–1.47) for each 0.1 increment. Further, both frailty (OR = 1.93, 95% CI 1.67–3.17) and pre-frailty (OR = 1.54, 95% CI 1.06–2.25) were associated with increased risk of elevated BNP.

Conclusion

FI is associated with increased risks of both cardiovascular events and surrogated endpoint of cardiovascular disease—elevated BNP. Frailty may be a non-traditional risk factor of cardiovascular diseases and frailty index may be a measurement for early identifying high risk elderly individuals of cardiovascular abnormities.

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Acknowledgements

We acknowledge all participants involved in the present study.

Funding

This work was financially supported by grants from the National Key R&D Program of China (2018YFC2000400, 2018YFC2002000), the National Natural Science Foundation of China (81571372, 81670465, 81600577), the Shanghai natural science grant (16ZR1449400).

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Author notes

  1. Zheng-Dong Wang and Shun Yao contributed equally to this work.

Authors and Affiliations

  1. Rugao People’s Hospital, Rugao, Jiangsu, China

    Zheng-Dong Wang, Guo-Ping Shi, Yong Wang, Jian-Ming Shi, Jiang-Hong Guo, Yin-Sheng Zhu & Xue-Feng Chu

  2. State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Science and Institutes of Biomedical Sciences, Fudan University, Shanghai, China

    Shun Yao & Xiao-Feng Wang

  3. National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China

    Shun Yao & Xiao-Feng Wang

  4. Key Laboratory of Arrhythmias of the Ministry of Education of China, Tongji University School of Medicine, Shanghai, China

    Xiao-Yan Jiang

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  1. Zheng-Dong Wang
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  2. Shun Yao
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Correspondence to Xue-Feng Chu or Xiao-Feng Wang.

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The Human Ethics Committee of the School of Life Sciences, Fudan University, Shanghai, People’s Republic of China, approved the present study.

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Wang, ZD., Yao, S., Shi, GP. et al. Frailty index is associated with increased risk of elevated BNP in an elderly population: the Rugao Longevity and Ageing Study. Aging Clin Exp Res 32, 305–311 (2020). https://doi.org/10.1007/s40520-019-01189-4

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  • DOI: https://doi.org/10.1007/s40520-019-01189-4

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