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Functional recovery in hip fracture patients: the role of pharmacotherapy

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Abstract

Background and aim

The aim of this prospective observational cohort study was to verify the relationship between number of drugs used and functional outcome in hip fracture patients undergoing rehabilitation.

Methods

This study was conducted on 139 patients with hip fracture who underwent a rehabilitation program. Efficiency rate in the Functional Independence Measure (FIM) and Berg Balance Scale (BBS), and length of stay (LOS) were the outcome measures.

Results

At the end of rehabilitation, 66.1% of patients showed an increase in number of drugs used, while 33.9% used the same or lower number of drugs than at admission. At the end of rehabilitation patients with increased pharmacotherapy took a higher total number of drug classes (p = 0.001), had longer LOS (p = 0.009) and lower Berg efficiency (p = 0.048) than patients with the same or lower pharmacotherapy. The number of drugs used at discharge was an independent determinant of LOS (beta = 0.19, p = 0.022) and FIM efficiency (beta = − 0.20, p = 0.025). Age was a determinant of LOS (beta = 0.17, p = 0.044) and BBS efficiency (beta = − 0.23, p = 0.009), while CIRS severity was a determinant of BBS efficiency only (beta = − 0.22, p = 0.016).

Discussion

Findings of study indicate that in hip fracture patients, the number of drugs prescribed at discharge is an important indicator of LOS and rehabilitation efficiency.

Conclusions

These findings can help the physician to better plan the rehabilitation of hip fracture patients who require polypharmacy.

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Acknowledgements

The Authors thank Rosemary Allpress for English revision of the manuscript.

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Authors and Affiliations

  1. Operative Unit for Recovery and Functional Rehabilitation of the Institute of Lumezzane, Istituti Clinici Scientifici Maugeri IRCCS, Via G. Mazzini, 129, Lumezzane, 25065, Brescia, Italy

    Bernardo Gialanella, Raffaele Santoro, Paola Prometti & Alessandro Giordano

  2. Operative Unit for Recovery and Functional Rehabilitation of the Institute of Lissone, Istituti Clinici Scientifici Maugeri IRCCS, Monza-Brianza, Italy

    Vittoria Monguzzi

  3. Istituti Clinici Scientifici Maugeri IRCCS, Scientific Direction of the Institute of Lumezzane, Brescia, Italy

    Laura Comini & Adriana Olivares

  4. Operative Unit for Recovery and Functional Rehabilitation of the Institute of Castel Goffredo, Istituti Clinici Scientifici Maugeri IRCCS, Mantova, Italy

    Giuseppe Grioni

Authors
  1. Bernardo Gialanella
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  2. Raffaele Santoro
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  3. Paola Prometti
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  4. Alessandro Giordano
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  5. Vittoria Monguzzi
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  6. Laura Comini
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  7. Adriana Olivares
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  8. Giuseppe Grioni
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Corresponding author

Correspondence to Bernardo Gialanella.

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Conflict of interest

The authors declare that they have no conflict of interest. The research was not supported by Pharmaceutical Companies. The research was supported by Institutional funding.

Statement of human and animal rights

The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Technical Scientific Committee of our Institute.

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Informed consent was obtained from all individual participants included in the study.

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Gialanella, B., Santoro, R., Prometti, P. et al. Functional recovery in hip fracture patients: the role of pharmacotherapy. Aging Clin Exp Res 32, 49–57 (2020). https://doi.org/10.1007/s40520-019-01175-w

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  • DOI: https://doi.org/10.1007/s40520-019-01175-w

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