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Biochemical markers of inflammation are associated with increased mortality in hip fracture patients: the Bispebjerg Hip Fracture Biobank

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Abstract

Purpose

The purpose of this study was to examine the possible association between mortality following a hip fracture and known biochemical markers of inflammation.

Methods

The study population was identified using two local databases from Bispebjerg Hospital (Copenhagen, Denmark): the Hip Fracture Database containing all patients admitted to the hospital with a fractured hip from 1996 to 2012 and the Hip Fracture Biobank, containing whole blood, serum and plasma taken in relation to admission on a subgroup of patients from the Hip Fracture Database, consecutively collected over a period of 2.5 years from 2008 to 2011. The following biochemical markers of inflammation were included: C-reactive protein (CRP), the soluble urokinase plasminogen activating receptor (suPAR), ferritin and transferrin. The association between the blood markers and mortality was examined using Cox proportional hazards models. Hazard ratios (HR) were expressed per quartile increase in the biochemical markers.

Results

A total of 698 patients were included, 69 (9.9%) died within 30 days after sustaining a hip fracture. The HR for 30-day mortality was significantly increased with increasing quartiles of suPAR, CRP and ferritin and with decreasing quartiles of transferrin.

Conclusion

This study shows that 30-day mortality after a hip fracture is associated with elevated levels of suPAR, CRP and ferritin as well as with lower levels of transferrin. This excess inflammatory response is likely caused by muscle damage associated with the hip fracture. However, this needs to be further clarified.

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Funding

This research was supported by a Grant from Region Zealand.

Author information

Authors and Affiliations

  1. Department of Clinical Biochemistry, Hvidovre Hospital, Kettegård Alle 30, 2650, Hvidovre, Denmark

    Debbie Norring-Agerskov, Lise Bathum & Henrik L. Jørgensen

  2. Department of Orthopedic Surgery, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400, Copenhagen NV, Denmark

    Debbie Norring-Agerskov & Jes B. Lauritzen

  3. Department of Clinical Immunology, Næstved Sygehus, Ringstedgade 61, 4700, Næstved, Denmark

    Ole B. Pedersen

  4. Department of Medicine, Holbæk Hospital, Smedelundsgade 60, 4300, Holbæk, Denmark

    Bo Abrahamsen

  5. Department of Clinical Biochemistry, Rigshospitalet Glostrup, Valdemar Hansens Vej 13, 2600, Glostrup, Denmark

    Niklas R. Jørgensen

  6. Odense Patient Data Explorative Network, University of Southern Denmark and Odense University Hospital, J.B. Winsløws Vej 9A, 5000, Odense C, Denmark

    Debbie Norring-Agerskov, Bo Abrahamsen & Niklas R. Jørgensen

  7. Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark

    Jes B. Lauritzen & Henrik L. Jørgensen

Authors
  1. Debbie Norring-Agerskov
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  2. Lise Bathum
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  3. Ole B. Pedersen
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  4. Bo Abrahamsen
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  5. Jes B. Lauritzen
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  7. Henrik L. Jørgensen
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Contributions

All authors have contributed significantly to the manuscript. Study design: all authors. Processing and preparation of raw data for subsequent analyses: BA, HLJ. Preparation of biobank material: DNA. Data analysis: DNA, HLJ. Interpretation of data: all authors. Drafting of the manuscript: DNA. Critical review of the manuscript for intellectual content and approval of final version: all authors. Guarantor: DNA.

Corresponding author

Correspondence to Debbie Norring-Agerskov.

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Conflict of interest

Debbie Norring-Agerskov, Lise Bathum, Ole B. Pedersen, Bo Abrahamsen, Jes B. Lauritzen, Niklas R. Jørgensen, and Henrik L. Jørgensen declare that they have no conflict of interest.

Statement of human and animal rights

The human data are derived from registers and the data were anonymized prior to our use. Animals were not used in this study.

Informed consent

In this case, informed consent from the individual patients is not required according to Danish law.

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Norring-Agerskov, D., Bathum, L., Pedersen, O.B. et al. Biochemical markers of inflammation are associated with increased mortality in hip fracture patients: the Bispebjerg Hip Fracture Biobank. Aging Clin Exp Res 31, 1727–1734 (2019). https://doi.org/10.1007/s40520-019-01140-7

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  • DOI: https://doi.org/10.1007/s40520-019-01140-7

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