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Neuroimaging correlates of lateral postural control in older ambulatory adults

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Abstract

Background

In older adults, impaired postural control contributes to falls, a major source of morbidity. Understanding central mechanisms may help identify individuals at risk for impaired postural control.

Aims

To determine the relationship between gray matter volume (GMV), white matter hyperintensities (WMH), mean diffusivity (MD), and fractional anisotropy (FA) with lateral postural control.

Methods

Neuroimaging and postural control were assessed in 193 community-dwelling older adults (mean age 82, 55.4% female, 44.6% black). GMV, WMH, and diffusion tensor-derived markers of microstructure (MD and FA) were quantified for total brain and regions of interest. Lateral postural control was defined as the root mean square error (RMSE) of lateral sway during a visual feedback test. Associations were assessed with linear regression, adjusted for total brain atrophy and risk factors for impaired postural control.

Results

RMSE was higher for women than men (p < 0.001) and inversely correlated with gait speed (r = − 0.20, p = 0.01), modified mini-mental state (r = − 0.27, p < 0.001), digit symbol substitution test (r = − 0.20, p = 0.01) and quadriceps strength (r = − 0.18, p = 0.01). RMSE was inversely associated with GMV of bilateral precuneus (r = − 0.26, p = 0.01) and FA of corpus callosum and selected tracts in the right hemisphere (anterior thalamic radiation, cingulum, inferior longitudinal and fronto-occipital fasciculi), independent of covariates (r = − 0.34 to − 0.18, p ≤ 0.04).

Discussion

Lower GMV and microstructural white matter integrity in selected networks can explain worse lateral postural control in older ambulatory adults without neurologic diseases.

Conclusion

Neuroimaging markers of poor postural control in healthy aging may help identify increased fall risk and design preventative fall strategies.

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Acknowledgements

This research was supported by National Institute on Aging (NIA) Contracts N01-AG-6-2101; N01-AG-6-2103; N01-AG-6-2106; NIA Grant R01-AG028050, and NINR Grant R01-NR012459. This research was funded in part by the Intramural Research Program of the NIH, National Institute on Aging. This research was supported by the University of Pittsburgh Older Americans Independence Center (NIH P30 AG024827).

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Authors and Affiliations

  1. Department of Neurology, University of Pittsburgh Medical Center, 811 Kaufmann Medical Building, 3471 Fifth Avenue, Pittsburgh, PA, 15213, USA

    Robyn E. Massa

  2. Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA

    Andrea Rosso, Andrea L. Metti, Ayushi Divecha & Caterina Rosano

  3. Department of Physical Therapy, University of Pittsburgh, Pittsburgh, PA, USA

    Patrick J. Sparto

  4. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA

    Howard Aizenstein

  5. Intramural Research Program, National Institute on Aging, Baltimore, MD, USA

    Luigi Ferrucci

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  1. Robyn E. Massa
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  2. Andrea Rosso
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Correspondence to Robyn E. Massa.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Massa, R.E., Rosso, A., Metti, A.L. et al. Neuroimaging correlates of lateral postural control in older ambulatory adults. Aging Clin Exp Res 31, 611–619 (2019). https://doi.org/10.1007/s40520-018-1028-4

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