Non-linear associations between sleep duration and the risks of mild cognitive impairment/dementia and cognitive decline: a dose–response meta-analysis of observational studies

Abstract

Background

Mount evidence from observational studies suggested that associations between sleep duration and the risks of mild cognitive impairment (MCI)/dementia or cognitive decline had been recognized.

Methods

To explore the precise and continuous effect of sleep duration on these risks, we conducted a dose–response meta-analysis to quantitatively assess it.

Results

Five prospective cohort studies and 4 cross-sectional studies were eligible for inclusion criteria, which involved 62937 individuals, and documented 2718 MCI/dementia cases and 5596 cognitive decline cases. The pooled RR per 1 h increases in sleep duration was 0.99 (95% CI 0.97–1.01, I2 = 62.40%, P = 0.02, n = 6) for cognitive decline risk, and 0.98 (95% CI 0.97–1.00, I2 = 0%, P = 0.42, n = 4) for MCI/dementia risk. Similar U-shaped non-linear relationship of sleep duration and the risks of MCI/dementia and cognitive decline was revealed, respectively (all Pnon-linearity < 0.001), whose peaks are approximately 7 h.

Conclusion

In conclusion, 7 h sleep duration tends to acquire the least risk of MCI/dementia or cognitive decline; however, more well-designed randomized controlled trials are urgently needed to balance potential modifiers.

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Abbreviations

MCI:

Mild cognitive impairment

RR:

Relative risk

CI:

Confidence interval

MMSE:

The mini-mental state examination

TICS:

Telephone interview for cognitive status

EBMT:

The east Boston memory test

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Funding

Supported by Medical Scientific Research Foundation of Guangdong Province, China (Grant No. A2017392) and Traditional Chinese Medicine Bureau Of Guangdong Province (Grant No. 20181184).

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YL wrote the main manuscript. HL provided the study idea. YL and LBQ conducted article screening and literature search. HL made critical comments and revision for the manuscript. All authors reviewed and approved the final manuscript.

Corresponding author

Correspondence to Hao Liu.

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Liang, Y., Qu, LB. & Liu, H. Non-linear associations between sleep duration and the risks of mild cognitive impairment/dementia and cognitive decline: a dose–response meta-analysis of observational studies. Aging Clin Exp Res 31, 309–320 (2019). https://doi.org/10.1007/s40520-018-1005-y

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Keywords

  • Sleep duration
  • Mild cognitive impairment (MCI)
  • Dementia
  • Cognitive decline
  • Dose–response
  • Meta-analysis