Mount evidence from observational studies suggested that associations between sleep duration and the risks of mild cognitive impairment (MCI)/dementia or cognitive decline had been recognized.
To explore the precise and continuous effect of sleep duration on these risks, we conducted a dose–response meta-analysis to quantitatively assess it.
Five prospective cohort studies and 4 cross-sectional studies were eligible for inclusion criteria, which involved 62937 individuals, and documented 2718 MCI/dementia cases and 5596 cognitive decline cases. The pooled RR per 1 h increases in sleep duration was 0.99 (95% CI 0.97–1.01, I2 = 62.40%, P = 0.02, n = 6) for cognitive decline risk, and 0.98 (95% CI 0.97–1.00, I2 = 0%, P = 0.42, n = 4) for MCI/dementia risk. Similar U-shaped non-linear relationship of sleep duration and the risks of MCI/dementia and cognitive decline was revealed, respectively (all Pnon-linearity < 0.001), whose peaks are approximately 7 h.
In conclusion, 7 h sleep duration tends to acquire the least risk of MCI/dementia or cognitive decline; however, more well-designed randomized controlled trials are urgently needed to balance potential modifiers.
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Mild cognitive impairment
The mini-mental state examination
Telephone interview for cognitive status
The east Boston memory test
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Supported by Medical Scientific Research Foundation of Guangdong Province, China (Grant No. A2017392) and Traditional Chinese Medicine Bureau Of Guangdong Province (Grant No. 20181184).
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The authors declare that there are no conflicts of interest.
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Liang, Y., Qu, LB. & Liu, H. Non-linear associations between sleep duration and the risks of mild cognitive impairment/dementia and cognitive decline: a dose–response meta-analysis of observational studies. Aging Clin Exp Res 31, 309–320 (2019). https://doi.org/10.1007/s40520-018-1005-y
- Sleep duration
- Mild cognitive impairment (MCI)
- Cognitive decline