Advertisement

Pentoxifylline in prosthetic valve: a case report

  • E. Disegna
  • A. De Caro
  • N. Nori
  • M. Taylor
  • F. Fantin
  • G. Mazzali
  • E. Zoico
  • S. Marchiotto
  • M. Zamboni
  • S. Gattazzo
  • A. P. Rossi
Case Report
  • 29 Downloads

Introduction

Hemolysis is a rare and potentially serious complication of prosthetic heart valves. It is usually associated with either structural deterioration or a paravalvular leak. Its main mechanism is a turbulent flow through the valve or between the sewing ring and the native ring.

The first case of valve-related hemolysis was described by Rose et al. in 1954, in a prosthetic valve prototype [1]. The reported rate of significant hemolysis has decreased from 15 to 5% in the 1960s and 1970s, then to less than 1% in the 1990s with the introduction of improved valve models [1].

In some patients, recurrent hemolysis refractory to supportive treatment may be an indication for valve replacement. However, in the aging population, the number of patients at high risk for valve replacement surgery has increased and the decision to replace the valve must be considered with caution.

In patients with severe hemolytic anemia in whom surgical repair should be avoided or referred, there are only...

Notes

Acknowledgements

The manuscript has been revised extensively by a native English speaker and medical writer, Prof Mark J Newman.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Gungunes A, Akpinar I, Dogan M, Baser K, Yildirim IS, Haznedaroglu IC (2010) Do all haemolytic anemias that occur after mitral valve repair require surgical treatment? Clin Cardiol 33:E76–E8CrossRefPubMedGoogle Scholar
  2. 2.
    Shapira Y, Vatury M, Sagie A (2009) Hemolysis associated with prosthetic heart valves: a review. Cardiol Rev 17:121–124CrossRefPubMedGoogle Scholar
  3. 3.
    Golbasi I, Turkay C, Timuragaoglu A et al (2003) The effect of pentoxifylline on haemolysis in patients with double cardiac prosthetic valves. Acta Cardiol 58:379–383CrossRefPubMedGoogle Scholar
  4. 4.
    Tyers GF, Jamieson WR, Munro AI et al (1995) Reoperation in biological and mechanical valve populations: fate of the reoperative patient. Ann Thorac Surg 60(Suppl):S464–S468PubMedGoogle Scholar
  5. 5.
    Mecozzi G, Milano AD, De Carlo M et al (2002) Intravascular hemolysis in patients with new generation prosthetic heart valves: a prospective study. J Thorac Cardiovasc Surg 123:550–556CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • E. Disegna
    • 1
  • A. De Caro
    • 1
  • N. Nori
    • 1
  • M. Taylor
    • 1
  • F. Fantin
    • 1
  • G. Mazzali
    • 1
  • E. Zoico
    • 1
  • S. Marchiotto
    • 2
  • M. Zamboni
    • 1
  • S. Gattazzo
    • 1
  • A. P. Rossi
    • 1
  1. 1.Section of Geriatrics, Department of MedicineUniversity of VeronaVeronaItaly
  2. 2.Anestesia e Rianimazione, Ospedale di BussolengoVeronaItaly

Personalised recommendations