Old age is a positive modifier of renal outcome in Taiwanese patients with stages 3–5 chronic kidney disease

Abstract

Background

The incidence of end-stage renal disease (ESRD) is increasing in elderly patients with chronic kidney disease (CKD). This contradicts the general notion that elderly people are more likely to die than to ever reach ESRD. And racial disparity in relation to age on kidney disease outcomes has always been a subject of research interest.

Aims

We investigated the effect of age on outcome in a cohort with stages 3–5 CKD patients by age category.

Methods

A total of 430 patients with a mean age of 65.6 years were enrolled and followed till death, ESRD, or end of 2015. Multivariable Cox regression was used to identify predictors of all-cause mortality. Competing risk-adjusted Cox regression was used to identify determinants of ESRD. The median follow-up was 7.3 (interquartile range 8.8) years.

Results

Cox regression showed old age and low mean arterial pressure were predictors of mortality before and after onset of ESRD. Competing risk analysis revealed patients aged 20–39 years and 40–64 years exhibited greater risks of ESRD, compared to those aged over 75 years. These effects of age on outcomes occurred independently of traditional risk factors such as low estimated glomerular filtration rate and high proteinuria.

Conclusions

Age over 75 years is associated with decreased risk for ESRD even after adjustment for competing mortality. Given the global trends in population aging, there is a need to develop age-specific strategies, on top of the existing stage-based measures, to optimize the management of CKD in the elderly.

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Acknowledgements

The authors acknowledge statistical assistance provided by the Center of Statistical Consultation and Research in the Department of Medical Research, National Taiwan University Hospital. This study was supported in part by grants from the National Taiwan University Hospital (105-003126), the Ta-Tung Kidney Foundation, and the Mrs Hsiu-Chin Lee Kidney Research Fund, Taipei, Taiwan.

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Correspondence to Yung-Ming Chen.

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This study was approved by the Research and Ethics Committee of the National Taiwan University Hospital.

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Chou, Y., Yen, C., Lai, T. et al. Old age is a positive modifier of renal outcome in Taiwanese patients with stages 3–5 chronic kidney disease. Aging Clin Exp Res 31, 1651–1659 (2019). https://doi.org/10.1007/s40520-018-01117-y

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Keywords

  • Age
  • Chronic kidney disease
  • End-stage renal disease
  • Mortality
  • Competing risk analysis