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Aging Clinical and Experimental Research

, Volume 30, Issue 7, pp 839–843 | Cite as

Comparative characteristic of antimicrobial resistance in geriatric hospital: a retrospective cohort study

  • G. Goltsman
  • E. H. Mizrahi
  • A. Leibovitz
  • G. Gal
  • O. Gorelik
  • E. Lubart
Original Article

Abstract

Background and aims

To examine antimicrobial resistance of commonly isolated pathogens in elderly hospitalized patients.

Methods

Data regarding all clinically significant isolates from blood and urine cultures of patients admitted to a multilevel geriatric hospital during March 2015 to April 2016 were collected. Antimicrobial susceptibility testing was performed according to Clinical and Laboratory Standard Institute guidelines.

Results

Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae were the most common isolates, with proportions of extended spectrum beta-lactamase positivity of 60, 40, and 61% respectively. Adjusted logistic regression models indicated that resistance of Escherichia coli to ceftriaxone [odds ratio (OR) 2.8, 95% confidence interval (CI) 1.5–5.1], ceftazidime (OR 2.8, 95% CI 1.5–5.1), ciprofloxacin (OR 2.2, 95% CI 1.2–4.0), amoxicillin/clavulanic acid (OR 2.3, 95% CI 1.2–4.3), and trimethoprim/sulfamethoxazole (OR 2.4, 95% CI 1.4–4.3) was significantly higher in skilled nursing wards than in acute geriatric wards. Resistance of Proteus mirabilis to ceftriaxone (OR 3.1, 95% CI 1.5–6.4) and Klebsiella pneumoniae to ciprofloxacin (OR 3.2, 95% CI 1.3–7.9) was significantly higher in skilled nursing wards than in acute wards.

Conclusions and discussion

Antimicrobial resistance was found to be high in a multilevel geriatric hospital, especially in skilled nursing wards. These findings call for rethinking of the empirical antimicrobial therapy and of the efforts for prevention of nosocomial infection.

Keywords

Antimicrobial resistance ESBL Infection Geriatric hospital 

Notes

Compliance with ethical standards

Funding

The study did not have specific funding.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was approved by the institutional ethical committee.

Statement of human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study, formal consent is not required.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • G. Goltsman
    • 1
    • 2
  • E. H. Mizrahi
    • 1
    • 3
  • A. Leibovitz
    • 1
    • 3
  • G. Gal
    • 4
  • O. Gorelik
    • 1
    • 2
  • E. Lubart
    • 1
    • 3
  1. 1.The Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  2. 2.Asaf Harofeh Medical CenterZerifinIsrael
  3. 3.Shmuel Harofeh Geriatric Medical CenterBeer YaakovIsrael
  4. 4.School of Behavioral SciencesTel Aviv-Jaffa Academic CollegeJaffaIsrael

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