Abstract
Background
Alzheimer’s disease (AD) research progress is impeded due to participant recruitment challenges. This study seeks to better understand, from the perspective of individuals engaged in clinical trials (CTs), research motivations.
Methods
Participants, or their caregivers, from AD treatment and prevention CTs were surveyed about research motivators.
Results
The 87 respondents had a mean age of 72.2, were predominantly Caucasian, 55.2% were male, and 56.3% had cognitive impairment. An overwhelming majority rated the potential to help themselves or a loved one and the potential to help others in the future as important motivators. Relatively few respondents were motivated by free healthcare, monetary rewards, or to make others happy.
Conclusions
Recruitment efforts should focus on the potential benefit for the individual, their loved ones, and others in the future rather than free healthcare or monetary rewards.
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References
Alzheimer’s Association (2015) 2015 Alzheimer’s disease facts and figures. Alzheimers Dement 11:332–384
Vellas B et al (2012) Alzheimer’s disease therapeutic trials: EU/US task force report on recruitment, retention, and methodology. J Nutr Health Aging 16:339–345
Knebl JA, Patki D (2010) Recruitment of subjects into clinical trials for Alzheimer disease. J Am Osteopath Assoc 110(9 Suppl 8):S43–S49
McDonald AM et al (2006) What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies. Trials 7:1–8
Watson JL et al (2014) Obstacles and opportunities in Alzheimer’s clinical trial recruitment. Health Aff (Millwood) 33:574–579
Grill JD et al (2013) Risk disclosure and preclinical Alzheimer’s disease clinical trial enrollment. Alzheimers Dement 9:356.e1–359.e1
Treweek S et al (2013) Methods to improve recruitment to randomised controlled trials: Cochrane systematic review and meta-analysis. BMJ Open 3:e002360
Grill JD, Karlawish J (2010) Addressing the challenges to successful recruitment and retention in Alzheimer’s disease clinical trials. Alzheimers Res Ther 2:34
Cooper C, Ketley D, Livingston G (2014) Systematic review and meta-analysis to estimate potential recruitment to dementia intervention studies. Int J Geriatr Psychiatry 29:515–525
Williams, MM et al. (2010) Barriers and facilitators of African American participation in Alzheimer disease biomarker research. Alzheimer Dis Assoc Disord 24(Suppl):S24–S29.
Acknowledgements
The authors thank all study participants and study partners who participate in research at our site and across the globe and particularly thank those who took the time to complete this survey.
Author contributions
SHB analyzed the data and wrote the paper. SDH and GAJ planned the study, provided insights into analysis, and contributed to revising the paper.
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Funding
The authors have no funding to acknowledge for this research.
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Data availability
The data sets during and/or analyzed during the current study available from the corresponding author on reasonable request.
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Bardach, S.H., Holmes, S.D. & Jicha, G.A. Motivators for Alzheimer’s disease clinical trial participation. Aging Clin Exp Res 30, 209–212 (2018). https://doi.org/10.1007/s40520-017-0771-2
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DOI: https://doi.org/10.1007/s40520-017-0771-2