Aging Clinical and Experimental Research

, Volume 30, Issue 2, pp 161–168 | Cite as

Characteristics of advanced gastric cancer with negative or only perigastric lymph node metastasis in elderly patients

  • Hajime Fujishima
  • Yoshitake Ueda
  • Norio Shiraishi
  • Takao Hara
  • Michihiro Ichimanda
  • Yuki Shitomi
  • Hidefumi Shiroshita
  • Tsuyoshi Etoh
  • Masafumi Inomata
Original Article



After gastrectomy with extended lymph node (LN) dissection, the damage of celiac plexus seems to cause of disorder of eating habits. To clarify the indication of gastrectomy with limited LN dissection for elderly patients, the pathological characteristics of advanced gastric cancer in elderly patients were examined in this study.


Forty-seven patients aged ≥80 years with advanced gastric cancer (deeper than pT2) who underwent curative gastrectomy from 1998 to 2015 were enrolled. Patients were classified into two groups by extent of LN metastasis: Group A, with N0 or only perigastric LN metastasis (n = 33); Group B, LN metastasis beyond the perigastric area (n = 14). Pathological factors were then evaluated.


No significant differences were observed in age, sex, body mass index, American Society of Anesthesiologists physical status classification, serum level of carcinoembryonic antigen, surgical procedure, extent of LN dissection, and number of dissected LNs. Pathological findings showed no significant differences in tumor location, macroscopic type, histologic type, and lymphovascular invasion. However, significant differences were observed in tumor maximum diameter at the cut-off level of 40 mm (Group A: ≤40 mm, n = 10 and >40 mm, n = 23; Group B: ≤40 mm, n = 0 and >40 mm, n = 14; P = 0.02).


In the elderly patients, LN metastasis in advanced gastric cancer of ≤40 mm in diameter was limited to be within the perigastric area. Gastrectomy with only perigastric LN dissection may be adopted in these patients.


Advanced gastric cancer Elderly patients Lymph node metastasis Tumor size Pathological characteristics 


Authors contribution

Study concept and design: FH, UY, and SN. Data acquisition: HT, IM, and SY. Quality control of data and algorithms: FH. Data analysis and interpretation: SH and ET. Manuscript preparation and editing: FH, UY, and SN. Manuscript review: SN and IM.

Compliance with ethical standards

Conflict of interest

All authors disclose no conflicts of interest relevant to this study. This study did not receive any funding from any sources.


This study did not receive any funding from any sources.

Ethical approval

This study was approved by the Ethical Committee of Oita University Faculty of Medicine.

Informed consent

All patients included in the study gave their written informed consent.


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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • Hajime Fujishima
    • 1
  • Yoshitake Ueda
    • 2
  • Norio Shiraishi
    • 2
  • Takao Hara
    • 1
  • Michihiro Ichimanda
    • 1
  • Yuki Shitomi
    • 1
  • Hidefumi Shiroshita
    • 1
  • Tsuyoshi Etoh
    • 1
  • Masafumi Inomata
    • 1
  1. 1.Department of Gastroenterological and Pediatric SurgeryOita University Faculty of MedicineOitaJapan
  2. 2.Center for Community MedicineOita University Faculty of MedicineOitaJapan

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